OBR Daily Commentary

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Opdivo (nivolumab) in Combination with Yervoy (ipilimumab) Demonstrates Clinical Activity in Previously Treated Patients with dMMR or MSI-H Metastatic Colorectal Cancer

(Morningstar) Jan 20, 2018 - Bristol-Myers Squibb Company today announced new data from a cohort of the phase 2 CheckMate -142 trial evaluating Opdivo (nivolumab) and Yervoy (ipilimumab) for the treatment of patients with DNA mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC).

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Howard S. Hochster, MD (Posted: January 22, 2018)

quotesGreat work by Mike Overman and colleagues showing prolonged benefit to Nivo (3 mg,kg) and Ipi (1 mg,kg) given x 4 doses. Median duration of response not yet reached and over one year. This does suggest the combo is more active than single agent Nivo. But randomized trials are needed in this rare MSI-high population. Now possible in the NRG/SWOG COMMIT trial available on CTSU. Please screen your patients early and consider this for first line therapy. After all, MSI-high patients have great responses to chemo also. Order may matter.quotes

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First-Time Data for Merck’s KEYTRUDA® (pembrolizumab) in Patients with Previously Treated Advanced Hepatocellular Carcinoma (HCC) to be Presented at 2018 ASCO GI Symposium

(Merck) Jan 19, 2018 - Merck, known as MSD outside the United States and Canada, today announced findings from the registrational phase 2 KEYNOTE-224 trial investigating the use of KEYTRUDA® (pembrolizumab), the company’s anti-PD-1 therapy, in patients with advanced hepatocellular carcinoma (HCC), the most common type of liver cancer, who were previously treated with systemic therapy (sorafenib).

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Howard S. Hochster, MD (Posted: January 19, 2018)

quotesThe Keynote-224 is only a phase 2 study of good performance, very well selected HCC patients after sorafenib. But with a 16% response rate and 77% 6-month survival (median survival not yet reached), this is unprecedented good news for HCC patients. Median time on study was 8 months, which could amount to a very meaningful extension of life. The main question is whether these results will be seen with a more real-life patient population. But these data confirm what is seen with nivolumab and show a real benefit compared to other options in HCC (e.g regorafenib after sorafenib).quotes

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DNA Mutations Shed in Blood Predicts Response to Immunotherapy in Patients with Cancer

(UC San Diego Health) Oct 1, 2017 - In a first-of-its-kind study, University of California San Diego School of Medicine researchers report that a blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies.

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Howard S. Hochster, MD (Posted: October 02, 2017)

quotesThis interesting study from Kurzrock and colleagues looks at circulating tumor DNA (ctDNA) to determine who may benefit from immunotherapy. The study included 69 patients with various diagnoses. With more than 3 mutations detected on the 70-gene panel the response rate was 45% in this group compared with 15% for those with 3 or fewer mutations. Presumably this is closely linked with the calculated "tumor mutation burdern" score. This is a good step in the effort to define the utility of ctDNA which is determined on a blood draw and can be done serially. The title refers to this as "liquid biopsy" though in the old days it was just "phlebotomy" for a blood analysis. quotes

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Meet the Editorial Board

Prostate Cancer
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Tomasz M. Beer, MD, FACP

Professor of Medicine, Division of Hematology/Medical O...

Community Oncology
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Dean Gesme, MD

FACP FACPE FASCO President, Minnesota Oncology...

Breast Cancer
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Debu Tripathy, MD

Professor and Chair, Department of Breast Medical Oncol...

Lung Cancer
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H. Jack West, MD

Medical Director, Thoracic Oncology Program, Swedish Ca...

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Howard S. Hochster, MD

Distinguished Professor of Medicine, Rutgers Robert Woo...

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Howard Sandler, MD, MS, FASTRO

Ronald H. Bloom Chair in Cancer Therapeutics
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Robert A. Figlin, MD., FACP

Professor and Director, Division of Hematology Oncology...

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Ted Okon

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Thomas Marsland, MD

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Florida Cancer Specialists President and Managing Part...

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National Health Policy Expert...

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President, W-Squared Group...