OBR Daily Commentary

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Researchers Assess the Accuracy of 68Ga-PSMA-11 PET in Localizing Prostate Cancer

(UCSF) Apr 8, 2019 - Treatment of patients with biochemically recurrent prostate cancer is guided by disease location and extent.

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Howard Sandler, MD, MS, FASTRO (Posted: April 08, 2019)

quotesSome of the leaders in the US from UCLA and UCSF report on their Ga68 PSMA PET scan results in prostate cancer patients after surgery, after RT or after both. While PSMA PET has not been formally compared with fluciclovine PET, many expect PSMA PET to be superior imaging modality. Hopefully, we'll see some high quality comparison data and hopefully we'll have access to an FDA-cleared PSMA imaging modality soon.quotes

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Prophylactic Cranial Irradiation Improves Disease-Free Survival and Brain Metastasis Rates for Locally Advanced Non-Small Cell Lung Cancer

(NRG Oncology) Mar 18, 2019 - Prophylactic cranial irradiation (PCI), a technique used to prevent the clinical development of brain metastases, is established as a standard approach for many patients with small cell lung cancer (SCLC) after initial therapy. While studies established that PCI decreases the incidence of brain metastases for patients with locally advanced non-small cell lung cancer (LA-NSCLC), there is no established indication for its use for such NSCLC patients. Cumulative brain metastases (BM) rates are high for patients with LA-NSCLC. NRG Oncology conducted the NRG-RTOG 0214 trial to address this high incidence of brain metastases and determine if the addition of PCI following primary treatment improved overall survival (OS) in patients with LA-NSCLC.

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Howard Sandler, MD, MS, FASTRO (Posted: March 19, 2019)

quotesProphylactic cranial irradiation (PCI) is generally offered to patients with limited small cell lung cancer but hasn't been offered to non-small cell lung cancers. This prospective randomized study shows that PCI can alter the pattern of failure and has a large impact on the incidence of brain mets (HR = 0.43) but doesn't improve overall survival. Some toxicity has been reported as well. At this point, there would be little rationale for routine use of PCI in non-small cell lung cancer.quotes

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Radiation After Surgery Triples Survival For A Type Of Pediatric Brain Tumor

(St. Jude Children’s) Mar 1, 2019 - Radiation immediately following surgery in children with ependymoma, the third most common pediatric brain tumor, can nearly triple survival.

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Howard Sandler, MD, MS, FASTRO (Posted: March 05, 2019)

quotesThis COG study (of about 350 pediatric ependymoma patients) identified a benefit to RT even in the very young, <3 year old, patients with ependymoma. While RT is clearly risky when given to the very young, tumor recurrence in the posterior fossa is also associated with adverse effects. One could probably argue that carefully delivered posterior fossa RT is less toxic approach if local control can be substantially improved as was apparent in this large COG study. Congratulations to the pediatric brain tumor community.quotes

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Meet the Editorial Board

Prostate Cancer
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Tomasz M. Beer, MD, FACP

Professor of Medicine, Division of Hematology/Medical O...

Community Oncology
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Dean Gesme, MD

FACP FACPE FASCO President, Minnesota Oncology...

Breast Cancer
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Debu Tripathy, MD

Professor and Chair, Department of Breast Medical Oncol...

Lung Cancer
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H. Jack West, MD

Medical Director, Thoracic Oncology Program, Swedish Ca...

Gastrointestinal Cancers
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Howard S. Hochster, MD

Distinguished Professor of Medicine, Rutgers Robert Woo...

Radiation Oncology
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Howard Sandler, MD, MS, FASTRO

Ronald H. Bloom Chair in Cancer Therapeutics
Pr...

Community Oncology
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Jeff Patton, M.D.

CEO Tennessee Oncology...

Precision Medicine Section Editor
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Jennifer Levin Carter, MD, MPH

Chief Medical Officer and Founder, N-of-One...

Financial Sector
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Michael G. King Jr.

Managing Director and Senior Biotechnology Analyst...

Gastrointestinal Cancers
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Richard Goldberg, MD

Director WVU Cancer Institute Director of Cancer Signa...

Editor-In-Chief
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Robert A. Figlin, MD., FACP

Professor and Director, Division of Hematology Oncology...

Health Policy
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Ted Okon

Executive Director Community Oncology Alliance...

Community Oncology
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Thomas Marsland, MD

Vice President Integrated Community Oncology Network ...

Community Oncology
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William Harwin MD

Florida Cancer Specialists President and Managing Part...

Health Policy
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William McGivney, PhD

National Health Policy Expert...

Payer
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Winston Wong, PharmD

President, W-Squared Group...