OBR Daily Commentary

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Benefit of LDR Brachytherapy In Patients With Early-Stage Prostate Cancer Is Still Unclear

(IQWIG [Germany]) Nov 16, 2018 - Interstitial brachytherapy uses slightly radioactive particles implanted into the prostate to deliver radiation directly to the tumour (low-dose-rate, LDR). Due to a lack of conclusive data, it still remains an unresolved issue as to whether this procedure has advantages compared with other treatments in men with localized prostate cancer.

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Howard Sandler, MD, MS, FASTRO (Posted: November 19, 2018)

quotesIt's very challenging to run clinical trials when patients are randomized to very different treatment, such as radiation vs. surgery. LDR brachytherapy has strong data supporting its use but there are limited randomized comparisons. It has been shown to be a relatively low cost monotherapy for prostate cancer but has limited use in the US due to a learning curve and limited practitioner base with expertise. The ASCENDE RT trial suggested a benefit to LDR brachytherapy as a boost when compared to EBRT alone but this finding is somewhat controversial since the study has so far only showed a PSA benefit but not a MFS or OS benefit. quotes

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Radiotherapy Offers New Treatment Option for Liver Cancer

(RSNA) Apr 24, 2018 - A novel technique that delivers high doses of radiation to tumors while sparing the surrounding normal tissue shows promise as a curative treatment option for patients with early-stage liver cancer, according to a new study.

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Howard Sandler, MD, MS, FASTRO (Posted: April 24, 2018)

quotesInteresting experience using focal radiation techniques (with injected radiation) to treat HCC. There are many focal ablative treatments in the liver cancer space including chemoembolization, RFA, cryotherapy, external beam stereotactic radiation approaches. Important for us to improve these techniques as the HCC problem continues to grow! It would be nice to see comparative studies between techniques to help define relative advantages and disadvantages.quotes

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First Stereotactic Radiation Therapy System Designed To Treat Early Stage Breast Cancer Receives FDA Clearance

(University of Maryland School of Medicine) Dec 22, 2017 - The GammaPod ™ – a first-of-its kind stereotactic radiotherapy system to treat early stage breast cancer – has received 510(k) clearance from the U.S. Food and Drug Administration (FDA), paving the way for the manufacturer to bring the system to market for the treatment of breast cancer patients.

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Howard Sandler, MD, MS, FASTRO (Posted: January 02, 2018)

quotesInteresting concept and interesting that it made it thru small business grant all the way to FDA 510(k) approval. Now comes the real challenging part: Is there a market for a breast-cancer specific radiation treatment device?quotes

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Meet the Editorial Board

Prostate Cancer
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Tomasz M. Beer, MD, FACP

Professor of Medicine, Division of Hematology/Medical O...

Community Oncology
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Dean Gesme, MD

FACP FACPE FASCO President, Minnesota Oncology...

Breast Cancer
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Debu Tripathy, MD

Professor and Chair, Department of Breast Medical Oncol...

Lung Cancer
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H. Jack West, MD

Medical Director, Thoracic Oncology Program, Swedish Ca...

Gastrointestinal Cancers
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Howard S. Hochster, MD

Distinguished Professor of Medicine, Rutgers Robert Woo...

Radiation Oncology
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Howard Sandler, MD, MS, FASTRO

Ronald H. Bloom Chair in Cancer Therapeutics
Pr...

Community Oncology
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Jeff Patton, M.D.

CEO Tennessee Oncology...

Precision Medicine Section Editor
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Jennifer Levin Carter, MD, MPH

Chief Medical Officer and Founder, N-of-One...

Financial Sector
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Michael G. King Jr.

Managing Director and Senior Biotechnology Analyst...

Gastrointestinal Cancers
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Richard Goldberg, MD

Director WVU Cancer Institute Director of Cancer Signa...

Editor-In-Chief
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Robert A. Figlin, MD., FACP

Professor and Director, Division of Hematology Oncology...

Health Policy
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Ted Okon

Executive Director Community Oncology Alliance...

Community Oncology
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Thomas Marsland, MD

Vice President Integrated Community Oncology Network ...

Community Oncology
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William Harwin MD

Florida Cancer Specialists President and Managing Part...

Health Policy
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William McGivney, PhD

National Health Policy Expert...

Payer
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Winston Wong, PharmD

President, W-Squared Group...