OBR Daily Commentary

forumImage

New Insights Into Treatment Targets For Men With Advanced Prostate Cancers

(Huntsman Cancer Institute) May 13, 2019 - In the largest study of its kind, more than half of patients with advanced prostate cancers appear to be strong candidates for targeted cancer therapies.

Read Article arrow

Tomasz M. Beer, MD, FACP (Posted: May 14, 2019)

quotesWhile it is undoubtedly exciting to find that more than half of the men with advanced prostate cancer have a genomic alteration which we may be able to match to a drug, this is a very long way indeed from demonstrating a patient benefit. There are countless examples of targeted drugs that yielded little or no benefit in prostate cancer and many other malignancies. This is an important first step, but what is needed next are careful studies that demonstrate what drugs can help which patients based on genomic findings. The routine use of such approaches outside of a clinical trial is not yet warranted with some very specific and not common exceptions. This is not yet an argument for molecularly directed therapy for more than half of our patients. quotes

Add Comment 1 Comment
forumImage

Does Hormone Therapy for Prostate Cancer Raise Dementia Risk?

(U.S. News & World Report/HealthDay News) May 5, 2019 - New research uncovers yet another possible downside to androgen-deprivation therapy for prostate cancer: Men may be at greater risk for dementia.

Read Article arrow

Tomasz M. Beer, MD, FACP (Posted: May 06, 2019)

quotesStudies of large populations have inherent limitations in their ability to account for confounders, so it is hard to be sure if hormone therapy really increases risk of dementia. And the story of hormones and dementia in general is complex. Research that directly addresses this question is needed. It is less clear that this information is sufficiently robust to use in treatment discussions and decisions. quotes

Add Comment 1 Comment
forumImage

AUA Releases New Clinical Guideline for Diagnosis and Treatment of Testicular Cancer

(AUA) May 2, 2019 - Today, the American Urological Association (AUA), a leading global urology association, released a new clinical guideline on the diagnosis and treatment of early stage testicular cancer.

Read Article arrow

Tomasz M. Beer, MD, FACP (Posted: May 02, 2019)

quotesThe additional of hormonal therapy to radiation in the salvage (rising PSA post prostatectomy setting is the new and impactful change to these practice guidelines. Clinicians should be aware of the potential benefits of adding hormonal therapy in this setting, and of the toxicities.quotes

Add Comment 1 Comment

Meet the Editorial Board

Prostate Cancer
member photo
Tomasz M. Beer, MD, FACP

Professor of Medicine, Division of Hematology/Medical O...

Community Oncology
member photo
Dean Gesme, MD

FACP FACPE FASCO President, Minnesota Oncology...

Breast Cancer
member photo
Debu Tripathy, MD

Professor and Chair, Department of Breast Medical Oncol...

Lung Cancer
member photo
H. Jack West, MD

Medical Director, Thoracic Oncology Program, Swedish Ca...

Gastrointestinal Cancers
member photo
Howard S. Hochster, MD

Distinguished Professor of Medicine, Rutgers Robert Woo...

Radiation Oncology
member photo
Howard Sandler, MD, MS, FASTRO

Ronald H. Bloom Chair in Cancer Therapeutics
Pr...

Community Oncology
member photo
Jeff Patton, M.D.

CEO Tennessee Oncology...

Precision Medicine Section Editor
member photo
Jennifer Levin Carter, MD, MPH

Chief Medical Officer and Founder, N-of-One...

Financial Sector
member photo
Michael G. King Jr.

Managing Director and Senior Biotechnology Analyst...

Gastrointestinal Cancers
member photo
Richard Goldberg, MD

Director WVU Cancer Institute Director of Cancer Signa...

Editor-In-Chief
member photo
Robert A. Figlin, MD., FACP

Professor and Director, Division of Hematology Oncology...

Health Policy
member photo
Ted Okon

Executive Director Community Oncology Alliance...

Community Oncology
member photo
Thomas Marsland, MD

Vice President Integrated Community Oncology Network ...

Community Oncology
member photo
William Harwin MD

Florida Cancer Specialists President and Managing Part...

Health Policy
member photo
William McGivney, PhD

National Health Policy Expert...

Payer
member photo
Winston Wong, PharmD

President, W-Squared Group...