OBR Daily Commentary - Colorectal

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Colon and Rectal Cancers Surge Among Millennials and Generation X

(USA Today) Feb 28, 2017 - Colon and rectal cancers have increased dramatically and steadily in millennials and Generation X adults in the United States over the past four decades, a study confirmed Tuesday.

Richard Goldberg (Posted: March 01, 2017)

quotesThis finding may make us rethink screening guidelines that already call for African Americans to begin screening at age 45 because of that group's propensity for earlier onset disease. Additionally genetic screening for heritable predisposition to colorectal cancer is particularly vital in those with early onset cancer to permit the development of individualized screening recommendations for family members.quotes

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Study Examines 'Watch-And-Wait' Approach for People with Rectal Cancer

(St. Michael's Hospital [Toronto, Canada]) May 5, 2017 - In a paper published online today in The Lancet Gastroenterology & Hepatology, researchers conducted a systematic review and meta-analysis of 23 studies involving 867 patients with rectal cancer who adopted the “watch-and-wait” approach. Cancer returned in the rectum of only 15.7 per cent of these patients.

Richard Goldberg, MD (Posted: May 05, 2017)

quotesThis is a very interesting study that opens the door to prospective investigation of a randomized trial of watch and wait strategy versus surgery in patients with low stage rectal cancers who have complete responses to chemotherapy and radiation. Identifying patients who can be spared the cost and toxicity of triple modality therapy with good outcomes is key.quotes

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Metastatic Colorectal Cancer Patients Treated First-line With SIR-Spheres® Y-90 Resin Microspheres More Likely to Become Candidates for Potentially Curative Liver Surgery, REsect Study Shows

(Sirtex) May 24, 2017 - Adding selective internal radiation therapy (SIRT) with SIR-Spheres Y-90 resin microspheres to first-line FOLFOX-based chemotherapy was associated with a statistically significant gain in potentially curative liver resectability, an independent, international panel of expert liver surgeons has reported.

Howard S. Hochster, MD (Posted: June 01, 2017)

quotesReaders beware!! This is a "thought" experiment where a committee of hepatic surgeons decided on resectability of the hepatic metastases based on CT scans from the SIRTEX colon studies. It doesn't mean all the patients would be resectable (many may have occult extra-hepatic disease at time of surgery) and eligibility did NOT require liver only disease. Until actual resection data and survival statistics are presented, this should be regarded as an "in cerebro" experiment only.quotes

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Meet the Editorial Board

Community Oncology
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Dean Gesme, MD

FACP FACPE FASCO President, Minnesota Oncology...

Breast Cancer
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Debu Tripathy, MD

Professor and Chair, Department of Breast Medical Oncol...

Lung Cancer
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H. Jack West, MD

Medical Director, Thoracic Oncology Program, Swedish Ca...

Gastrointestinal Cancers
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Howard S. Hochster, MD

Associate Cancer Center Director, Yale Cancer Center P...

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Jeff Patton, M.D.

CEO Tennessee Oncology...

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Chief Medical Officer and Founder, N-of-One...

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Michael G. King Jr.

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Gastrointestinal Cancers
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Richard Goldberg, MD

Director WVU Cancer Institute Director of Cancer Signa...

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Robert A. Figlin, MD., FACP

Professor and Director, Division of Hematology Oncology...

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Ted Okon

Executive Director Community Oncology Alliance...

Community Oncology
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Thomas Marsland, MD

Vice President Integrated Community Oncology Network ...

Community Oncology
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William Harwin MD

Florida Cancer Specialists President and Managing Part...

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William McGivney, PhD

National Health Policy Expert...

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President, W-Squared Group...