OBR Daily Commentary - Lymphoma (includes NHL, HL, CNS Lymphoma)

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After Negative PET, Drop Bleomycin in Hodgkin's Lymphoma

(Medscape Medical News) June 22, 2016 - A response-adapted approach to the treatment of patients with advanced Hodgkin's lymphoma de-escalates treatment after an early negative PET scan and intensifies treatment in those with a PET-positive scan — those with the highest risk for treatment failure.

William McGivney, PhD (Posted: June 26, 2016)

quotesThis study is a game changer in providing data that supports stopping bleomycin in patients who are PET negative after two cycles of ABVD. However the real game changer may be the results of the phase III trial of front line treatment for advanced-stage Hodgkin's disease comparing ABVD with Seattle Genetic's brentuximab vedotin plus AVD (ClinicalTrials.gov NCT01712490) expected in 2017. If a positive study, as per the editorial in this week's NEJM, it may result in a "new standard of care for the first time in nearly three decades.”quotes

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Novartis's Next Challenge: Pricing Breakthrough Cancer Treatment

(Bloomberg) June 8, 2017 - Novartis AG, set to beat Kite Pharma Inc. to the finish line in one of the most promising new areas of cancer research, is examining how to price a revolutionary therapy patients will need to take just once.

admin (Posted: June 08, 2017)

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Dean Gesme, MD

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