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NCCN Updates Lung Cancer Guideline, Again

(Medscape Medical News) Mar 24, 2017 - It's only March, but the National Comprehensive Cancer Network (NCCN) has already issued five updates of its 2017 non–small cell lung cancer (NSCLC) guidelines, as clinical practice continues to rapidly change, according to presenters here at the group's annual meeting.

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H. Jack West, MD (Posted: March 24, 2017)

quotesIt's striking that we've needed yet another revision of the NCCN guidelines in NSCLC, but this is a reflection of how rapid the progress has been in the field. Adding PD-L1 expression testing at initial workup, including revised indications for the second line use of the various PD-1 and PD-L1 inhibitors, and including data on the very clear positive results for osimertinib in T790M-positive acquires resistance after first line EGFR Takis -- these are all valuable additions. Whether frustrating or encouraging, additional revisions will likely follow in the coming months, as new data lead to further rapid evolution of our standards of care in advanced NSCLC.quotes

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