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Roche’s Alecensa Beats Pfizer’s Xalkori In Lung Cancer Trial

(PharmaTimes [UK]) Apr 10, 2017 - Roche has presented late-stage data showing that its Alecensa was superior to Pfizer’s Xalkori on progression-free survival in patients with a specific type of lung cancer.

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H. Jack West, MD (Posted: April 10, 2017)

quotesIn the wake of the highly positive preceding phase II version of this trial in Japanese ALK-positive patients (J-ALEX), we debated whether these results were compelling enough to warrant a change in first line treatment of ALK-positive but ALK inhibitor-naive patients. While that remains debatable, many thoughtful observers of this space have favored waiting until we obtained results from the larger and more demographically/geographically diverse phase III ALEX trial of alectinib vs. crizotinib, which also studied the global standard dose of alectinib (600 mg PO BID) rather than a unique lower dosing (300 mg PO BID) studied in the Japanese only population. We need to see the data, and I hope and expect that will occur at ASCO 2017 (in either the lung cancer oral abstracts on 6/6/17 or, even better, as part of the Plenary program on 6/4/17). However, now knowing that this trial was positive, as we had expected, these results should be enough to shift alectinib to become the standard of care for first line treatment of advanced ALK-positive NSCLC in the coming months.quotes

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