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Much Shorter Chemo Works For Many Colon Cancer Patients, Study Says

(Washington Post/To Your Health) June 4, 2017 - Many colon cancer patients can cut their chemotherapy regimen in half, improving their quality of life and reducing their chances of having debilitating side effects, according to a major international study released Sunday.

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Howard S. Hochster, MD (Posted: June 05, 2017)

quotesThe combined analysis of more than 12000 patients in 6 randomize trial was intended to show a noninferiority of 3 months FOLFOX or CapeOX with 95% confidence. As it turned out the HR = 1.07 with 95%CI = 1.0 to 1.15 for the primary endpoint of 3 yr DFS (or 0.9% absolute difference). This means the we have 95% confidence that the shorter course may be equal as much as 1.8% worse at the most. It seems reasonable to assume these are as equal as possible to define. Also, across subsets of good risk (T3 or N1) 3 months was non-inferior. And CapeOX was more effective and non inferior across the board, though this was not a randomized assignment (physician choice in most studies). We can be comfortable that 3 months of CapeOX (and probably FOLFOX) is as good as 6 months treatment for good risk patients receiving adjuvant therapy. quotes

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