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CheckMate -078, a Pivotal, Multinational Phase 3 Opdivo (nivolumab) Lung Cancer Trial with Predominantly Chinese Patients, Stopped Early for Demonstrating Superior Overall Survival

(BMS) Nov 30, 2017 - Bristol-Myers Squibb Company announced today that the Phase 3 study CheckMate -078, evaluating Opdivo (nivolumab) versus docetaxel in previously treated advanced or metastatic non-small cell lung cancer (NSCLC), was stopped early because the independent Data Monitoring Committee (DMC) concluded that the study met its primary endpoint, demonstrating superior overall survival (OS) in patients receiving Opdivo compared with the control arm.

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H. Jack West, MD (Posted: December 01, 2017)

quotesWhile reassuring to see that the results in a Chinese population recapitatulate those seen in global phase 3 trials with other populations, these results only provide results I would have presumed to be the case. Reassuring, but it wasn't a question I would have had without these data. I have many Chinese patients and haven't hesitated to treat them with nivolumab in the second line setting based on the results of CheckMate-017 (for squamous NSCLC) and CheckMate-057 (for non-squamous NSCLC).quotes

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