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Lethal Prostate Cancer Treatment May Benefit from Combination Immunotherapy

(Johns Hopkins) June 25, 2018 - Researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy (BKI) released a study investigating the use of combination checkpoint immunotherapy in the treatment of a lethal form of advanced prostate cancer. The study suggested a genetic subset of prostate cancer may benefit from this form of immunotherapy.

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Tomasz M. Beer, MD (Posted: June 25, 2018)

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Several interesting things about this study. Combination checkpoint inhibition has proven useful in other cancers, but is new to prostate cancer. Patient enrollment using the AR-V7 assays to select highest risk patients is novel and represents the first such study. Finally, the links between DNA repair defects and response extends prior findings and provides new evidence that this relationship may extend beyond microsatellite instability. This regimen is not ready for clinical use, but is of interest for further study.

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