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Increased Survival In Patients With Metastatic NSCLC Receiving Treatment In Academic Centers

(IASLC) Oct 10, 2018 - Patients with metastatic NSCLC receiving treatment at academic centers (ACs) have an increased 2-year survival compared to patients treated at community-based centers (CCs). An overall histology-dependent survival was also noted in patients with adenocarcinoma verses squamous cell carcinoma and varied by treatment facility. Lung cancer is the most common cancer and the leading cause of cancer-related death worldwide. There are two major types of lung cancer, small cell and non-small cell lung cancer (NSCLC). Roughly 85% of diagnosed lung cancers are NSCLC with about 40% of NSCLC patients presenting with stage IV metastatic disease. Adenocarcinoma histological subtype accounts for 40% of all NSCLC and squamous cell carcinoma histological subtype accounts for roughly 30%.

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H. Jack West, MD (Posted: October 11, 2018)

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Notably, these results that are coming from academic centers may stem from them having more expertise, more access to newer agents and clinical trials, or some combination of these issues, but selection bias due to differences in the patient populations is always an issue with retrospective database analyses. The patients treated at academic centers have a better performance status and socioeconomic support, including people, funds, and other resources that also contribute to better outcomes. This isn't to say that selection bias explains the difference, but there are many contributing factors, and there is no question that the patients who receive care at academic centers are not the same population as those who don't, and these differences skew toward better results in these patients.

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