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Astellas and Pfizer Announce Positive Top-Line Results from Phase 3 ARCHES Trial of XTANDI® (enzalutamide) in Men with Metastatic Hormone-Sensitive Prostate Cancer

(Astellas) Dec 20, 2018 - Astellas Pharma Inc. and Pfizer Inc. today announced that the Phase 3 ARCHES trial evaluating XTANDI® (enzalutamide) plus androgen deprivation therapy (ADT) in men with metastatic hormone-sensitive prostate cancer (mHSPC) met its primary endpoint, significantly improving radiographic progression-free survival (rPFS) versus ADT alone.

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Tomasz M. Beer, MD, FACP (Posted: December 20, 2018)

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Intensification of therapy for newly diagnosed metastatic prostate cancer has become standard of care as a result of positive results with docetaxel and with abiraterone. It is not unexpected, therefore, that a similar approach with enzalutamide would yield favorable results. We will await eagerly the detailed results to better understand the effect of this combination.

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