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Lilly's CYRAMZA® (ramucirumab) Phase 3 Data in First-Line EGFR-Mutated Non-Small Cell Lung Cancer Published in The Lancet Oncology

(Lilly) Oct 7, 2019 - CYRAMZA, in combination with erlotinib, significantly delayed disease progression in previously untreated patients with metastatic non-small cell lung cancer whose tumors have activating EGFR mutations. In the RELAY study, treatment with CYRAMZA in combination with erlotinib demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) – the time patients lived without their cancer growing or spreading after starting treatment – compared to erlotinib alone.

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H. Jack West, MD (Posted: October 07, 2019)

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Though the progression-free survival (PFS) for this global trial is very encouraging, we've seen other work out of Japan on erlotinib + VEGF inhibitor (bevacizumab previously) demonstrate a highly significant improvement in PFS that didn't translate into an improvement in overall survival (OS). I would say that based on the Japanese research, plus with the added burden of regular IV infusions added to an otherwise oral regimen, and the lack of CNS activity compared to the competing standard of osimertinib, I don't think this combination regimen will gain much traction in the absence of further follow-up demonstrating a significant OS benefit.

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