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Featured Oncology News

NCCN Updates Lung Cancer Guideline, Again

(Medscape Medical News) Mar 24, 2017 - It's only March, but the National Comprehensive Cancer Network (NCCN) has already issued five updates of its 2017 non–small cell lung cancer (NSCLC) guidelines, as clinical practice continues to rapidly change, according to presenters here at the group's annual meeting.

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FDA Grants Approval for BAVENCIO® (avelumab), the First Immunotherapy Approved for Metastatic Merkel Cell Carcinoma

(Pfizer) Mar 23, 2017 - Only FDA-approved treatment for metastatic Merkel cell carcinoma, a rare and aggressive skin cancer; first indication for BAVENCIO, a human anti-PD-L1 antibody.

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New Research Suggests Random Chance Plays A Bigger Role In Getting Cancer

(Minneapolis Star Tribune/Associated Press) Mar 23, 2017 - Cancer patients often wonder "why me?" Does their tumor run in the family? Did they try hard enough to avoid risks like smoking, too much sun or a bad diet?

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Oncology Clinical News

Preterm Births More Common in Mothers Who Are Cancer Survivors

(UNC Health Care) Mar 23, 2017 - For young women facing a new cancer diagnosis, fertility preservation can be an important consideration in treatment planning. Now a University of North Carolina Lineberger Comprehensive Cancer Center-led study has identified potential risks for mothers who are cancer survivors -- risks for their newborns’ health.

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‘First in Human’ Trial Defines Safe Dosage for Small Molecule Drug ONC201 for Solid Cancer Tumors

(Rutgers/CINJ) Mar 22, 2017 - A ‘first in human’ clinical trial examining the small molecule drug ONC201 in cancer patients with advanced solid tumors shows that this investigational drug is well tolerated at the recommended phase II dose.

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MSK Researchers Identify First Evidence of Epigenetic Role in Breast Cancer

(MSK) Mar 23, 2017 - This is the first time that the epigenetic landscape of breast cancer patients treated with PI3K inhibitors has been studied.

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Mass. General Team Identifies Mechanisms Behind Resistance to FGFR Inhibitor Drug

(Mass General) Mar 23, 2017 - First evidence of clinical FGFR resistance identified in patients with liver tumors.

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Team of Scientists Demonstrate Path for Tackling Rare Cancers with No Effective Treatment

(Mount Sinai Hospital) Mar 23, 2017 - An international team of scientists led by the Icahn School of Medicine at Mount Sinai and UConn School of Medicine have reported the results of a genome sequencing study for an extremely rare form of cancer.

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CancerLocator Tool Aims to Non-Invasively Diagnose Cancer, Pinpoint Tissue of Origin

(GenomeWeb) Mar 24, 2017 - Researchers have developed an approach to glean whether blood samples contain tumor DNA and in which tissue that tumor, if present, is located.

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‘Jumonji’ Protein Key to Ewing’s Sarcoma Metastasis

(UCCC/Colorado Cancer Blogs) Mar 24, 2017 - By the time Ewing's Sarcoma is diagnosed, primarily in teens and young adults, it has often spread from its primary site to other parts of the body, making it difficult to treat.

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Oncology Business and Policy News

New NCCN Radiation Therapy Compendium™ Aids in Decision-Making for Patients with Cancer

(NCCN) Mar 23, 2017 - Launched during the NCCN 22nd Annual Conference, the new NCCN Radiation Therapy Compendium™ provides a single access point for radiation therapy recommendations within the NCCN Guidelines®.

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Merck Says EMA's CHMP Adopts Positive Opinion Recommending Approval Of KEYTRUDA

(NASDAQ/RTTNews.com) Mar 24, 2017 - Merck said Friday that the Committee for Medicinal Products for Human Use or CHMP of the European Medicines Agency or EMA has adopted a positive opinion recommending approval of KEYTRUDA (pembrolizumab), the company's anti-PD-1 therapy, for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma or cHLwho have failed autologous stem cell transplant or ASCT and brentuximab vedotin or BV, or who are transplant-ineligible and have failed BV.

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Updated Information: March 29, 2017: Oncologic Drugs Advisory Committee Meeting Announcement

(FDA.gov) Mar 22, 2017 - The afternoon session of the Oncologic Drugs Advisory Committee meeting that was to discuss new drug application (NDA) 209099, for binimetinib, submitted by Array BioPharma Inc. has been CANCELLED. The meeting is no longer needed.

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FDA Provides Cornerstone Pharmaceuticals Approval to Initiate Pivotal Study for CPI-613, its Metabolism-Directed Anticancer Compound

(Cornerstone Pharmaceuticals) Mar 23, 2017 - Successful end-of-phase I Type B meetings with FDA clears way for pivotal trials in acute myeloid leukemia (AML) and pancreatic cancer.

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New Article from CancerLinQ LLC Leadership Discusses the Need for Interoperability in Improving Population Health

(ASCO in Action) Mar 23, 2017 - On March 15, HIMMS News published an article authored by CancerLinQ LLC Chief Operating Officer Rich Ross that discusses the need for interoperability to for big data efforts to be successful.

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Senator Apologizes for Joke About Losing Mammogram Benefits

(TIME/Motto) Mar 23, 2017 - A Republican Senator apologized for joking about losing his mammogram benefits under the GOP’s proposed health care bill.

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New Era In Precision Medicine For Pancreatic Cancer

(Cancer Research UK) Mar 24, 2017 - The development of new treatments for pancreatic cancer is set to be transformed by a network of clinical trials, aiming to find the right trial for the right patient, after a £10 million investment from Cancer Research UK.

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NICE Asks BMS For More Data Before Approving Cancer Drug

(European Pharmaceutical Review) Mar 24, 2017 - The National Institute or Health and Care Excellence (NICE) has published new draft guidance recommending that Bristol Myers Squibb, who manufacture nivolumab (Opdivo), provide more information on its drug’s effectiveness for treating Hodgkin lymphoma.

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Bristol-Myers Squibb Receives Positive CHMP Opinion Recommending Opdivo (nivolumab) for the Treatment of Squamous Cell Cancer of the Head and Neck in Adults Progressing on or After Platinum-based Therapy

(BMS) Mar 24, 2017 - Bristol-Myers Squibb Company today announced that the Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Opdivo as monotherapy for the treatment of squamous cell cancer of the head and neck (SCCHN) in adults progressing on or after platinum-based therapy.

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Broader Healthcare and Pharma News

Drug Companies Are Buying Ads on Shows They Know Donald Trump Watches

(Bloomberg) Mar 23, 2017 - The top trade association for U.S. drugmakers is spending more on television advertising than any other special-interest group, part of a multi-year campaign to repair the industry’s reputation and counter President Donald Trump’s claims that it’s “getting away with murder” on pricing.

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FDA Fast-Tracks Genentech’s Rituxan

(Drug Store News) Mar 24, 2017 - The U.S. Food and Drug Administration granted Breakthrough Therapy Designation status to Genentech’s Rituxan, intended for the treatment of pemphigus vulgaris, a painful, disfiguring and potentially fatal autoimmune disease characterized by progressive blistering of skin and/or mucous membranes.

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GOP Health-Care Bill: Trump, Ryan Confer at the White House Amid Sustained Opposition

(Washington Post/PowerPost) Mar 24, 2017 - House Speaker Paul D. Ryan (R-Wis.) headed to the White House midday to brief President Trump on an overhaul of the nation’s health-care system, amid mounting evidence that enough House Republican would spurn their pitches and send the bill to defeat.

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