AACR Conference Coverage

Patient’s Immune Status Associated with Outcome Following Third-generation CAR T–Cell Therapy

(AACR) Sep 5, 2017 - Treatment with third-generation CAR T–cell therapy led to a complete response in six of 15 patients with a CD19-positive B-cell malignancy and overall survival was associated with the patient’s immune status, according to data from a phase I/IIa clinical trial presented at the Third CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival, held Sept. 6–9.

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Updated Data for Indoximod Plus KEYTRUDA® (pembrolizumab) Demonstrate Improvement of Response Rate for Patients with Advanced Melanoma

(NewLink) Sept 7, 2017 - Pivotal trial of indoximod in advanced melanoma to include both PD-1 Inhibitors, KEYTRUDA (pembrolizumab) and OPDIVO® (nivolumab).

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American Association for Cancer Research Releases 2017 Cancer Progress Report: Harnessing Research Discoveries to Save Lives

(AACR) Sept 13, 2017 - Immunotherapy and precision medicine continue to be at the forefront of progress.

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Forgoing Chemotherapy Linked to Worse Survival in Older Patients With Advanced Colon Cancer Who had Dementia

(AACR) Sept 22, 2017 - A pre-existing diagnosis of dementia was associated with increased risk of death for older patients with advanced colon cancer; however, some of the effects of dementia on survival could be mediated by receipt of chemotherapy, according to results of a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

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Inactivated Vaccinia Virus Safe and Effective Against Advanced Cancers Alone or in Combination with Immune Checkpoint Inhibitors

(AACR) Sep 5, 2017 - Modified vaccinia virus Ankara (MVA), a poxvirus, was found to be safe when administered in an inactivated form in mice, and delivering it into the tumor in addition to systemic delivery of an immune checkpoint inhibitor yielded synergistic antitumor effects in mice with large tumors and those with multiple tumors, according to data presented at the Third CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival, held Sept. 6-9.

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Gut Microbes May Promote Immune Responses Against Colorectal Cancer

(AACR) Sep 5, 2017 - Bacteria in the gut could stimulate tumor cells to produce factors that regulate cell mobility called chemokines that recruit T cells to the tumor, which is linked to improved outcomes, according to data presented at the Third CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival, held Sept. 6-9.

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Personalized Tumor Vaccines Keep Cancer in Check

(Science) Apr 12, 2017 - For half a century, researchers have dreamed of giving cancer patients a vaccine that helps the immune system detect the tumors as foreign tissue and wipe them out. But hundreds of attempts helped few patients.

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Which Patients Will Be Helped By Immune Cancer Drugs? This Test May Tell

(Forbes) Apr 12, 2017 - It's possible that tumor mutation burden (TMB) predicts if cancer―of any type―will respond to treatment with immune drugs, but this remains to be tested.

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Differences in Subtypes of Gastric Cancer May Determine Prognosis and Response to Treatment

(AACR) July 26, 2017 - Molecular classification of the four distinct subtypes of gastric cancer could potentially shape tailored treatment options by helping to predict survival outcomes and patients’ response to chemotherapy, according to results of a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

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Stand Up To Cancer Launches Four Teams on “Cancer Interception” To Detect and Treat Cancer at Earliest Stages

(AACR) Oct 26, 2017 – Stand Up To Cancer (SU2C), joined by the Lustgarten Foundation for Pancreatic Cancer Research, LUNGevity, and the American Lung Association, announced today four teams of top researchers who will carry out an attack on cancers of the lung and pancreas using a radical new approach of “interception” of cancers at very early stages, when they can be more successfully treated.

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Kura Oncology Lead Candidate Tipifarnib Shows Durable Anti-Tumor Activity in HRAS Mutant Head and Neck Cancer in AACR-NCI-EORTC Update

(Kura Oncology) Oct 27, 2017 - Kura Oncology, Inc. today presented updated preliminary results from its Phase 2 open-label trial of tipifarnib, a farnesyltransferase inhibitor, in patients with head and neck squamous cell carcinomas (HNSCC) with HRAS mutations.

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Tazemetostat Shows Early Promise for Children with Certain Relapsed or Refractory Solid Tumors

(2017 AACR-NCI-EORTC) Oct 27, 2017 - Children with relapsed or refractory malignant rhabdoid tumors, epithelioid sarcomas, or poorly differentiated chordomas with a particular genetic defect tolerated treatment with the investigational drug tazemetostat well and some had objective and durable responses, according to data from a phase I clinical trial.

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Genetic Alteration Allowing Lung Cancers to Escape the Immune System May Occur Late in Tumor Evolution

(2017 AACR-NCI-EORTC) Oct 26, 2017 - A specific genetic alteration that could allow cancer cells to escape the immune system was detected in 40 percent of non–small cell lung cancers (NSCLCs) analyzed, according to new data.

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Gene Therapy Shows Early Efficacy Against Recurrent Brain Cancer

(2017 AACR-NCI-EORTC) Oct 27, 2017 - More than a quarter of patients with recurrent high-grade glioma, a form of brain cancer, treated with the retroviral vector Toca 511 and the prodrug of the chemotherapy 5-fluorouracil, Toca FC, were alive more than three years after treatment, according to data from a subset of patients in a phase I clinical trial.

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Colorectal Cancers May Mutate to Escape Immune System Detection in Many Ways

(2017 AACR-NCI-EORTC) Oct 27, 2017 - Whole exome sequencing revealed that colorectal cancers with high mutational load (MSI-H) predominantly use “immunoediting” to escape immune surveillance while colorectal cancers with low mutational load (MSS) use oncogenic signaling to escape from the immune response, according to new data.

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New Colorectal Cancer Test Could Detect Early Cancer-causing Genetic Biomarkers with High Degree of Sensitivity

(2017 AACR-NCI-EORTC) Oct 27, 2017 - An investigational test that screens for colorectal cancer could detect genetic mutations that are indicative of the disease with a high degree of sensitivity and specificity, according to results of a new study.

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Number of Seamless Clinical Trials in Oncology Has Risen Recently

(2017 AACR-NCI-EORTC) Oct 27, 2017 - The number of early-phase trials in oncology that adopted a seamless approach, as opposed to a traditional trial approach with defined phase I, II, and III plans, is rising, with data from the majority of them presented after 2014, according to a new study.

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NCI-MATCH Reaches Central Patient-screening Goal

(2017 AACR-NCI-EORTC) Oct 27, 2017 - The National Cancer Institute (NCI) Molecular Analysis for Therapy Choice (MATCH) clinical trial has achieved the goal of screening nearly 6,000 patients in just under two years, according to new data.

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A Non-invasive Computational Imaging Approach May Help Predict Response to Immunotherapy

(2017 AACR-NCI-EORTC) Oct 27, 2017 - A computational imaging-based signature of immune-cell infiltration in and around a tumor could predict patients’ responses to treatment with anti-PD1/PDL1 immunotherapies, according to new data.

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African-American Women With Type 2 Diabetes May Have Higher Risk for ER-negative Breast Cancer

(AACR) Nov 15, 2017 - Among African-American women, those with type 2 diabetes may have a higher risk of developing estrogen receptor (ER)-negative breast cancer, according to results of a study published in Cancer Research, a journal of the American Association for Cancer Research.

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