Colorectal

Many Mutations In One Clinical-Trial Basket

(Nature.com) Jan 31, 2018 - When abnormality in a gene is linked to cancer and a drug targets the encoded protein, how can the patients who will respond to the drug be identified if the gene is mutated in many different ways in many different cancers?

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Developing New Cancer Treatments Is Vitally Important, But So Is Looking After Cancer Survivors

(Forbes) Feb 6, 2018 - Thanks to new treatments, more people are surviving cancer than ever before, with over 15 million cancer survivors in the U.S. alone. But what happens to these people after treatment and is the healthcare system equipped to provide for them?

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New Analysis Finds Patients Receiving Chemotherapy for Cancer at ADCC Institutions Have Highest Survival Rates

(Alliance of Dedicated Cancer Centers) Feb 6, 2018 - Patients treated with some of the most common types of cancer with chemotherapy at Dedicated Cancer Centers have higher survival rates compared to patients treated at other types of hospitals, according to new analysis conducted by Milliman for the Alliance of Dedicated Cancer Centers.

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Cancer 'Super Assassin': Huntington's Disease Molecule Can Target And Kill All Tumor Cells, Scientists Find

(Newsweek) Feb 12, 2018 - Scientists have destroyed numerous types of human cancer cells with a toxic molecule characteristic of fatal genetic illness Huntington’s disease.

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Bacteria Play Critical Role In Driving Colon Cancers

(Johns Hopkins Medicine) Feb 1, 2018 - Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds.

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Gut Microbes Combine to Cause Colon Cancer, Study Suggests

(New York Times) Feb 1, 2018 - Two types of bacteria commonly found in the gut work together to fuel the growth of colon tumors, researchers reported on Thursday.

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Immunotherapy Combo Active in High-Risk CRC

(MedPage Today) Jan 22, 2018 - More than half of patients with previously treated metastatic colorectal cancer and DNA mismatch repair deficiency (dMMR) had objective responses to the immunotherapy combination of nivolumab (Opdivo) and ipilimumab (Yervoy), results of a cohort study showed.

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Nivolumab's Durable Responses in MMR/MSI Colorectal Cancer

(Medscape Medical News) Jan 26, 2018 - There are now more data to support the use of nivolumab (Opdivo, Bristol-Meyers Squibb) as a treatment for DNA mismatch repair-deficient (dMMR)/microsatellite instability–high (MSI-H) metastatic colorectal cancer (mCRC), either as a monotherapy or in combination.

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No Survival Benefit with Bevacizumab Maintenance in CRC

(MedPage Today) Jan 28, 2018 - Bevacizumab (Avastin) monotherapy did not improve survival when used as maintenance treatment after induction chemotherapy in metastatic colorectal cancer, researchers found.

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Exercising During Chemotherapy for Breast or Colon Cancer Has Long-Term Benefits

(2018 Cancer Survivorship Symposium) Feb 12, 2018 - A follow-up study to a randomized clinical trial reveals that exercising during adjuvant (post-surgery) chemotherapy helps people engage in more physical activity years later.

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High Cancer-Related Expenses Take A Toll On Quality Of Life

(Reuters Health) Feb 13, 2018 - Cancer survivors who face a higher financial burden with their treatment and recovery tend to report lower quality of life and higher distress, a new study shows.

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Exact Targets Large Hospital Systems to Boost Sales of Cancer Test

(Xconomy Wisconsin) Feb 22, 2018 - Exact Sciences is setting its sights on large hospital systems across the country as part of an effort to get more doctors to order Cologuard, Exact’s stool-based DNA test for colorectal cancer screening, for their patients.

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Scientists Grow 'Mini Tumours' Which Enable Cancer Patients To Have Tailor Made Treatment

(The Telegraph [UK]) Feb 22, 2018 - Scientists have discovered a way to develop “tailor-made” cancer treatment - by testing drugs on “mini-tumours” grown in the lab.

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Lab-grown ‘Mini Tumours’ Could Personalise Cancer Treatment

(Cancer Research UK) Feb 22, 2018 - Testing cancer drugs on miniature replicas of a patient’s tumour could help doctors tailor treatment, according to new research.

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Kinase Inhibitor Larotrectinib Shows Durable Anti-tumor Abilities In Patients Of All Ages With 17 Unique Cancer Diagnoses

(MD Anderson) Feb 21, 2018 - Three simultaneous safety and efficacy studies of the drug larotrectinib reported an overall response rate of 75 percent for patients ages four months to 76 years with 17 different cancer diagnoses.

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Updated Data Confirms a Durable 75 Percent Overall Response Rate, by Blinded Independent Review, of Larotrectinib in Adults and Children with Tumors Harboring TRK Fusions

(MSK) Feb 21, 2018 - Larotrectinib, a highly selective TRK kinase inhibitor, shows rapid, potent, and durable efficacy in both adult and pediatric patients with solid tumors that harbor TRK fusions, regardless of tumor type or patient age, according to results from three clinical trials published in the New England Journal of Medicine.

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Researchers Develop Novel Immunotherapy To Target Colorectal Cancer

(Yale News) Feb 12, 2018 - A Yale-led research team has developed an antibody that blocks tumors in animal models of colorectal cancer. If the finding is confirmed in clinical trials, the antibody-based treatment could become an effective weapon against colorectal cancer, and possibly other cancers, that resist current immunotherapies, the researchers said.

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KRAS Targeted Cancer Strategy Shows Early Promise

(NIH Director’s Blog) Feb 13, 2018 - Recently, I was excited to hear of progress in targeting a specific mutant form of KRAS, which is a protein encoded by a RAS gene involved in many lung cancers and some pancreatic and colorectal cancers.

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Can You Vaccinate Yourself Against Cancer?

(CNN) Feb 21, 2018 - Could we someday be vaccinated against deadly tumors? Here's a look at the past, present and future of cancer vaccine research.

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Add Broken DNA Repair To The List Of Inherited Colorectal Cancer Risk Factors

(Broad Institute) Feb 22, 2018 - An analysis of nearly 3,800 colorectal cancer patients — the largest germline risk study for this cancer to date — reveals opportunities for improved risk screening and, possibly, treatment.

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