Colorectal

BRAFTOVI® (encorafenib) in Combination with MEKTOVI® (binimetinib) and ERBITUX® (cetuximab) or panitumumab Recommended by the National Comprehensive Cancer Network® (NCCN) Guidelines as a Treatment Option for Patients with Advanced BRAF-mutant Colorectal Cancer

(Morningstar) Mar 18, 2019 - Array BioPharma Inc. today announced that the National Comprehensive Cancer Network® (NCCN®) has updated their Clinical Practice Guidelines in Oncology for Colon and Rectal Cancer to include BRAFTOVI® in combination with MEKTOVI® and an anti-EGFR antibody as a Category 2a treatment for patients with BRAFV600E-mutant metastatic colorectal cancer (mCRC), after failure of one or two prior lines of therapy for metastatic disease.

read article

Early-Life Exposure To Microbiota Restricts Colon Cancer Later In Life, Study Finds

(GSU) Mar 13, 2019 - Exposure to microbiota, or microorganisms such as bacteria, in the early stages of life plays a crucial role in establishing optimal conditions in the intestine that inhibit the development of colon cancer in adulthood, according to a study led by Georgia State University.

read press release

NCCN Awards Grants to Investigators to Study Trifluridine and Tipiracil in Various Cancers

(NCCN) Mar 14, 2019 - The studies will be funded through a collaboration between the NCCN Oncology Research Program and Taiho Oncology, Inc. to investigate the effectiveness of trifluridine and tipiracil.

read press release

Biocartis Inks Cancer CDx Deal With Bristol-Myers Squibb

(GenomeWeb) Mar 12, 2019 - Belgian molecular diagnostics firm Biocartis announced today that it has partnered with Bristol-Myers Squibb to develop a companion diagnostic for a number of cancer immunotherapies, with an initial focus on colorectal cancer (CRC).

read article (free registration required)

Colon Cancer Screening Can Save Your Life

(New York Times) Mar 11, 2019 - With colorectal cancer being found in an increasing number of younger adults, the pressure is on to screen millions more.

read article

Colorectal Cancer in Patients with Early Onset is Distinct from That in Older Patients

(Wiley) Mar 11, 2019 - New research indicates that colorectal cancer diagnosed at an early age has clinical and genetic features that are different from those seen in traditional colorectal cancer diagnosed later in life.

read press release

Combinatorial Signature Outperforms Standard-of-care Methods in Stratifying Colorectal Cancer Patients for Prognosis

(AACR) Mar 7, 2019 - A method that integrates tumor buds, lymphocytic infiltration, and their spatial relationship could better stratify patients with stage 2 colorectal cancer (CRC) at high risk for disease-specific death compared with traditional methods of clinical staging, according to results published in Cancer Immunology Research, a journal of the American Association for Cancer Research.

read press release

2019 Symposium Features Noteworthy Research on Immunotherapy for Cancer

(2019 ASCO-SITC) Mar 1, 2019 – Nine studies exploring a variety of trends and approaches in immuno-oncology, including adaptive cell therapies, immune checkpoint inhibitors, the use of predictive biomarkers, and more, will be presented at the 2019 ASCO-SITC Clinical Immuno-Oncology Symposium.

read press release

WVU Researchers Pursue Blood Test For Colorectal Cancer

(WVU Today) Mar 4, 2019 - Researchers at the West Virginia University Cancer Institute are evaluating a first-of-its-kind blood test for detecting colorectal cancer. Their findings may help propel the test toward inclusion in the U.S. Preventive Services Task Force’s recommendations for colorectal cancer screening.

read article

Roche, Merck Upset By Removal Of Cancer Drug Coverage In Indonesia

(The Jakarta Post [Indonesia) Feb 28, 2019 - Pharmaceutical companies say they are disappointed by the government’s decision to stop covering the costs of drugs used for colorectal cancer therapy by the national health insurance (JKN), saying that it would hurt their business and also sacrifice cancer patients.

read article

Survey of Young-onset Colorectal Cancer Patients Suggests Misdiagnosis May Be Common

(AACR) Feb 27, 2019 - Many patients diagnosed with colorectal cancer before age 50 were initially misdiagnosed, which may lead to diagnosis at an advanced stage of the disease, according to survey results presented during a media preview of the AACR Annual Meeting 2019, to be held March 29-April 3, in Atlanta. “Despite declining incidence in older adults, there has been a rapid and alarming rise in colorectal cancer incidence among young adults in recent decades,” said the study’s lead author, Ronit Yarden, PhD, MHSA, director of medical affairs at the Colorectal Cancer Alliance, a patient advocacy organization based in Washington, D.C. “We do not yet know the cause of the rising incidence in younger patients, and there is little awareness of this trend among health care providers.”

read press release

Nektar Therapeutics Announces Several Preclinical Data Presentations for its Immuno-oncology Pipeline Candidates at the American Association for Cancer Research (AACR) Annual Meeting 2019

(The Street) Feb 27, 2019 - Nektar Therapeutics today announced several preclinical data presentations for its immuno-oncology pipeline candidates, bempegaldesleukin* (NKTR-214), a CD122-preferential IL-2 pathway agonist, and NKTR-255, an IL-15 receptor agonist, at the AACR Annual Meeting 2019.

read article

Annual Stool Test May Be As Effective As Colonoscopy, Study Finds

(NBCNews.com) Feb 26, 2019 - When it comes to colon cancer screening, an annual stool test may be as effective as colonoscopy for people who don’t have risk factors for the disease, a new study suggests.

read article

Discovery of Colon Cancer Pathway Could Lead to New Targeted Treatments

(UMass Amherst) Feb 25, 2019 - University of Massachusetts Amherst food science researchers have pinpointed a set of enzymes involved in tumor growth that could be targeted to prevent or treat colon cancer.

read press release

Medicaid Expansion In Kentucky Led To An Increase In Screening And Improved Survival For Colorectal Cancer Patients

(FACS) Feb 22, 2019 - The number of low-income patients screened for colorectal cancer more than tripled after Medicaid expansion in 2014, according to study findings in the Journal of the American College of Surgeons.

read press release

Salk Scientists Uncover How High-Fat Diet Drives Colorectal Cancer Growth

(Salk Institute) Feb 21, 2019 - A new study led by Salk Institute scientists suggests that high-fat diets fuel colorectal cancer growth by upsetting the balance of bile acids in the intestine and triggering a hormonal signal that lets potentially cancerous cells thrive.

read press release

Racial Disparities In US Cancer Deaths Are Shrinking, Study Finds

(CNN) Feb 14, 2019 - Racial disparities in cancer deaths between black and white patients in the United States are receding -- but more progress is needed to completely close the gap for some cancer types and age groups, according to a new study. Among men, the overall cancer death rate was 47% higher for blacks than for whites in 1990, but that difference dropped to 19% in 2016, and the disparity has been nearly eliminated in men younger than 50, according to the study published in CA: A Cancer Journal for Clinicians on Thursday. Among women, the disparity decreased from 19% in 1990 to 13% in 2016 and was nearly eliminated for women 70 and older.

read article

A Man On A Mission: How One Patient Journey Can Change The Course Of A Hereditary Cancer

(Forbes) Feb 8, 2019 - The staggering number of those who may be carriers of an alteration in a gene that commonly causes colorectal cancer and/or endometrial cancer and not know it is what really sets Lynch syndrome apart.

read article

Study Examines Aspirin Use To Prevent Colorectal Cancer

(Florida Atlantic University) Feb 7, 2019 - Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor. The U.S. Preventive Services Task Force (USPSTF) concluded that aspirin reduces the risk of colorectal cancer by 40 percent as well as recurrence of advanced polyps.

read article

Sedentary Lifestyle Could Increase Risk Of Colorectal Cancer In Young Women

(NBCNews.com) Feb 5, 2019 - For the first time, a scientific study has identified sedentary behavior as a potential risk factor to explain the sharp rise in colorectal cancer among those under 50.

read article
Next Page