Genentech Inc. / Roche (DNA)

Oncology Corporate Profile

HQ Location

1 DNA Way
South San Francisco, CA 94080

Company Description

Genentech has been delivering on the promise of biotechnology for more than 30 years, using human genetic information to discover, develop, manufacture and commercialize biotherapeutics that address significant unmet medical needs. Today, Genentech is among the world's leading biotech companies, with multiple products on the market and a promising development pipeline. In March 2009, Genentech became a wholly owned member of the Roche Group.

Website: http://www.gene.com

Brand Generic Indication
Alecensa«•alectinibALECENSA is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK) - positive, metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This indication is approved under accelerated approval based on tumor response rate and duration of response.
Avastin«•bevacizumabAvastin is a vascular endothelial growth factor-specific angiogenesis inhibitor indicated for the treatment of:



_Ê¢ Metastatic colorectal cancer, with intravenous 5-fluorouracil_Ê_based chemotherapy for first- or second-line treatment.



_Ê¢ Non-squamous non-small cell lung cancer, with carboplatin and paclitaxel for first line treatment of unresectable, locally advanced, recurrent or metastatic disease.



_Ê¢ Metastatic breast cancer, with paclitaxel for treatment of patients who have not received chemotherapy for metastatic HER2-negative breast cancer.



-Effectiveness based on improvement in progression-free survival. No data available demonstrating improvement in disease-related symptoms or survival with Avastin.



-Not indicated for disease progression following anthracycline and taxane chemotherapy administered for metastatic disease.



_Ê¢ Glioblastoma, as a single agent for patients with progressive disease following prior therapy.



-Effectiveness based on improvement in objective response rate. No data available demonstrating improvement in disease-related symptoms or survival with Avastin.



_Ê¢ Metastatic renal cell carcinoma with interferon alfa.



_Ê¢ In combination with chemotherapy for

the treatment of women with platinum-resistant, recurrent ovarian cancer.
Cotellic__¢CobimetinibCOTELLIC is a kinase inhibitor indicated for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib.
Erivedge«•vismodegibErivedge«• (vismodegib) capsule is indicated for the treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation.
Gazyva«•obinutuzumabGAZYVA (obinutuzumab) is a CD20-directed cytolytic antibody and is indicated:



- in combination with chlorambucil, for the treatment of patients with previously untreated chronic lymphocytic leukemia.



- in combination with bendamustine followed by GAZYVA monotherapy, for the treatment of patients with follicular lymphoma (FL) who relapsed after, or are refractory to, a rituximab-containing regimen.
Herceptin«•trastuzumabAdjuvant Breast Cancer



Herceptin is indicated for adjuvant treatment of HER2 overexpressing node positive or node negative (ER/PR negative or with one high risk feature breast cancer



_Ê¢ as part of a treatment regimen consisting of doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel



_Ê¢ with docetaxel and carboplatin



_Ê¢ as a single agent following multi-modality anthracycline based therapy.



Metastatic Breast Cancer



Herceptin is indicated:



_Ê¢ In combination with paclitaxel for first-line treatment of HER2-overexpressing metastatic breast cancer



_Ê¢ As a single agent for treatment of HER2-overexpressing breast cancer in patients who have received one or more chemotherapy regimens for metastatic disease.

Kadcyla__¢ado-trastuzumab emtansineKADCYLA is a HER2 targeted antibody and microtubule inhibitor conjugate indicated, as a single agent, for the treatment of patients with HER2-positive, metastatic breast cancer who previously received trastuzumab and a taxane, separately or in combination.



Patients should have either:

_Ê¢ Received prior therapy for metastatic disease, or

_Ê¢ Developed disease recurrence during or within six months of completing adjuvant therapy.

Kytril«•granisetron HCLKytril«• (granisetron HCL) is indicated for the prevention of:



Nausea and vomitting associated with initial and repeat courses of emetogenic cancer therapy, including high does cisplatin.



Nausea and vomitting associated with radiation, including total body irradiation and fractionated abdominal radiation.
Perjeta__¢pertuzumabPERJETA__¢ (pertuzumab) is a HER2/neu receptor antagonist indicated in combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease.
Rituxan«•rituximabNon_Ê_Hodgkin_Ê_s Lymphoma (NHL)



Rituxan«• (rituximab) is indicated for the treatment of patients with:



_Ê¢ Relapsed or refractory, low-grade or follicular, CD20-positive, B-cell NHL as a single agent



_Ê¢ Previously untreated follicular, CD20-positive, B-cell NHL in combination with CVP chemotherapy



_Ê¢ Non-progressing (including stable disease), low-grade, CD20-positive, B-cell NHL, as a single agent, after first-line CVP chemotherapy



_Ê¢ Previously untreated diffuse large B-cell, CD20-positive NHL in combination with CHOP or other anthracycline-based chemotherapy regimens



Chronic Lymphocytic Leukemia (CLL)

Rituxan«• (rituximab) is indicated, in combination with fludarabine and cyclophosphamide (FC), for the treatment of patients with previously untreated and previously treated CD20-positive CLL.
Roferon-A«•Interferon alfa-2a, recombinantRoferon-A is indicated for the treatment of chronic hepatitis C and hairy cell leukemia in patients 18 years of age or older. In addition, it is indicated for chronic phase Philadelphia chromosome (PH) positive chronic myelogenous leukemia (CML) patients who are minimally pretreated (within 1 year of diagnosis).
Tarceva«•erlotinibTARCEVA is a kinase inhibitor indicated for:



_Ê¢ Maintenance treatment of patients with locally advanced or metastatic non-small cell lung

cancer (NSCLC) whose disease has not progressed after four cycles of platinum-based fi rst-line

chemotherapy



_Ê¢ Treatment of locally advanced or metastatic non-small cell lung cancer after failure of at least one

prior chemotherapy regimen.



_Ê¢ First-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer,

in combination with gemcitabine.
Tecentriq?Tecentriq? is a programmed death-ligand 1 (PD-L1) blocking antibody indicated for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy; who have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. Metastatic non-small cell lung cancer who have disease progression during or following platinum-containing chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA approved therapy for these aberrations prior to receiving Tecentriq?
Vesanoid«•tretinoinVESANOID (tretinoin) capsules are indicated for the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant), characterized by the presence of the t(15;17) translocation and/or the presence of the PML/RARalpha gene who are refractory to, or who have relapsed from, anthracycline chemotherapy, or for whom anthracycline-based chemotherapy is contraindicated. VESANOID is for the induction of remission only. The optimal consolidation or maintenance regimens have not been defined, but all patients should receive an accepted form of remission consolidation and/or maintenance therapy for APL after completion of induction therapy with VESANOID.
Xeloda«•capecitabineColorectal Cancer



* XELODA is indicated as a single agent for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred. XELODA was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS). Although neither XELODA nor combination chemotherapy prolongs overall survival (OS), combination chemotherapy has been demonstrated to improve disease-free survival compared to 5-FU/LV. Physicians should consider these results when prescribing single-agent XELODA in the adjuvant treatment of Dukes' C colon cancer.

* XELODA is indicated as first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred. Combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone. A survival benefit over 5-FU/LV has not been demonstrated with XELODA monotherapy. Use of XELODA instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage.



Breast Cancer



* XELODA in combination with docetaxel is indicated for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy.

* XELODA monotherapy is also indicated for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated, eg, patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents. Resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen.
Zelboraf__¢vemurafenibZELBORAF__¢ is a kinase inhibitor indicated for the treatment of patients with unresectable or metastatic melanoma with BRAFV600E mutation as detected by an FDA-approved test.



Limitation of Use: ZELBORAF is not recommended for use in patients with

wild-type BRAF melanoma.

View additional information on commercial products here »

  • Brand
  • Generic
  • Investigational
Brand / Product Class Area of Study Phase Partnership
trastuzumab emtansineantibody drug conjugate1st line metastatic Breast cancer (HER2+)III
trastuzumab emtansineantibody drug conjugate3rd line metastatic Breast cancer (HER2+)III
obinutuzumab / GA101anti-CD20 monoclonal antibodyDiffuse large B-cell Lymphoma (DLBCL)III
obinutuzumab / GA101anti-CD20 monoclonal antibodyFront-line chronic lymphocytic leukemiaIII
obinutuzumab / GA101anti-CD20 monoclonal antibodyFront-line indolent non-Hodgkin's lymphomaIII
cobimetinib / GDC-0973selective MEK inhibitorMelanomaIII
obinutuzumab / GA101anti-CD20 monoclonal antibodyRefractory indolent Non Hodgkin's lymphomaIII
Avastin / bevacizumabanti-VEGF monoclonal antibody1st line metastatic Ovarian cancerIII
Avastin / bevacizumabanti-VEGF monoclonal antibodyAdjuvant Breast cancer (HER2+)III
Avastin / bevacizumabanti-VEGF monoclonal antibodyAdjuvant Breast cancer (HER2-)III
Avastin / bevacizumabanti-VEGF monoclonal antibodyGlioblastoma Multiforme (GBM)III
Avastin / bevacizumabanti-VEGF monoclonal antibodyNon Small Cell Lung Cancer (NSCLC)III
Avastin / bevacizumabanti-VEGF monoclonal antibodyVarious cancer typesIII
Perjeta / pertuzumabmonoclonal antibodyEarly Breast cancer (HER2+)III
Tarceva / erlotinibEGFR inhibitor1st line metastatic Non Small Cell Lung Cancer (NSCLC)III
Zelboraf / vemurafenibBRAF kinase inhibitorMelanomaIII
GDC-0810selective estrogen receptor degrader (SERD)Breast cancer (HER2-)II
polatuzumab vedotinantibody drug conjugateDiffuse large B-cell Lymphoma (DLBCL)II
ipatasertib / GDC-0068pan-Akt inhibitorGastric cancerII
alectinibselective ALK (anaplastic lymphoma kinase) inhibitorNon Small Cell Lung Cancer (NSCLC)II
polatuzumab vedotinantibody drug conjugateNon-Hodgkin's Lymphoma (NHL)II
ipatasertib / GDC-0068pan-Akt inhibitorProstate cancerII
ipatasertib / GDC-0068pan-Akt inhibitorTriple negative Breast cancerII
Erivedge / vismodegibhedgehog pathway inhibitorBasal Cell Carcinoma (BCC)II
Perjeta / pertuzumabmonoclonal antibody2nd line metastatic Breast cancer (HER2+)II
Perjeta / pertuzumabmonoclonal antibodyGastric cancerII
Zelboraf / vemurafenibBRAF kinase inhibitorThyroid cancerII
taselisib / GDC-0032PI3K InhibitorBreast cancer (HER2+)I
GDC-0077PI3K InhibitorBreast cancer (HER2-)I
GDC-0927selective estrogen receptor degrader (SERD)Breast cancer (HER2-)I
taselisib / GDC-0032PI3K InhibitorBreast cancer (HER2-)I
venetoclax / GDC-0199Bcl-2 selective inhibitorChronic Lymphocytic Leukemia (CLL)I
anti-CD20/CD3TDB antibodyLymphomaI
atezolizumabmonoclonal antibody targeting PD-L1MelanomaI
unknownantibody drug conjugateNon-Hodgkin's Lymphoma (NHL)I
venetoclax / GDC-0199Bcl-2 selective inhibitorNon-Hodgkin's Lymphoma (NHL)I
unknownantibody drug conjugateOvarian cancerI
unknownantibody drug conjugatePancreatic cancerI
anti-TIGITmonoclonal antibodyVarious cancer typesI
anti-OX40monoclonal antibodyVarious cancer typesI
atezolizumabmonoclonal antibody targeting PD-L1Various cancer typesI
GDC-0919IDO inhibitorVarious cancer typesI
GDC-0575CHK1 inhibitorVarious cancer typesI
cobimetinib / GDC-0973selective MEK inhibitorVarious cancer typesI
ipatasertib / GDC-0068pan-Akt inhibitorVarious cancer typesI
GDC-0077PI3K InhibitorVarious cancer typesI
taselisib / GDC-0032PI3K InhibitorVarious cancer typesI
Zelboraf / vemurafenibBRAF kinase inhibitorMetastatic MelanomaI

View additional information on product candidates here »

Source


http://www.gene.com

Recent News Headlines

Exelixis Announces Presentation of Cobimetinib Combination Therapy Data at the Society for Melanoma Research 2016 Congress That Support Genentech’s Planned Phase 3 Pivotal Trials

11/7/2016 06:56 am

(Yahoo! Finance) Nov 7, 2016 - Encouraging data in BRAF wild type advanced melanoma presented in advance of initiation of phase 3 pivotal trial next year; the third pivotal phase 3 trial of cobimetinib announced this year, reflecting robust late-stage development program.

Stand Up To Cancer Announces SU2C Catalyst™ Collaboration with Genentech to Support New Research on Cancer Treatments and Therapies

11/4/2016 11:03 am

(AACR) Nov 3, 2016 - Stand Up To Cancer (SU2C) announced today an SU2C Catalyst™ collaboration with Genentech, a member of the Roche Group, that will help accelerate the development of new cancer treatments and combination therapies by giving awardees funding and access to a dozen of the company's medicines.

Novogen Licenses Phase II-Ready Molecule from Genentech for Development in Glioblastoma

10/31/2016 10:33 am

(MarketWatch) Oct 30, 2016 - Licensing of GDC-0084, a small molecule phosphoinositide-3-kinase (PI3K) inhibitor developed by Genentech, is ready to enter a phase II clinical trial in glioblastoma multiforme (GBM).

FDA Approves Genentech’s Cancer Immunotherapy Tecentriq® (Atezolizumab) for People with a Specific Type of Metastatic Lung Cancer

10/18/2016 03:52 pm

(Genentech) Oct 18, 2016 - First and only anti-PDL1 cancer immunotherapy approved by the FDA for metastatic non-small cell lung cancer (NSCLC); approval based on survival benefit of TECENTRIQ compared to docetaxel chemotherapy, regardless of PD-L1 status.

Exelixis Announces Genentech Presentation of Preliminary Phase 1b Results for the Combination of Cobimetinib, Vemurafenib and Atezolizumab at ESMO 2016 Congress

10/7/2016 10:58 am

(Yahoo! Finance) Oct 7, 2016 - Exelixis, Inc. today announced that its collaborator Genentech, a member of the Roche Group, will present preliminary results from a phase 1b clinical trial evaluating the safety and clinical activity of the triple combination of cobimetinib, vemurafenib, and atezolizumab in patients with previously untreated BRAF V600 mutation-positive advanced melanoma.

Roche's Genentech Receives FDA Breakthrough Therapy Designation for Alecensa in ALK-Positive NSCLC

10/4/2016 07:18 am

(StreetInsider) Oct 4, 2016 - This second Alecensa Breakthrough Therapy Designation was granted based on Phase III J-ALEX study.

Genentech to Develop Hanmi Cancer Candidate HM95573

9/29/2016 12:30 pm

(GEN) Sept 29, 2016 - Genentech, a member of the Roche Group, will develop and commercialize Hanmi Pharmaceutical’s Phase I cancer candidate HM95573 in most of the world, through a license agreement that could generate up to $910 million for the South Korean drug developer.

Personalized Cancer Vaccines Are Back — And Genentech Is Jumping Into The Fray

9/21/2016 12:08 pm

(San Francisco Business Times/BiotechSF) Sept 21, 2016 - Genentech Inc. will shell out an initial $310 million in a partnership with Germany's BioNTech to develop personalized cancer vaccines, the company said late Tuesday.

Genentech Provides Update on Phase III Study of Gazyva® in People With Previously Untreated Diffuse Large B-Cell Lymphoma

7/18/2016 06:50 am

(Morningstar) July 18, 2016 - GOYA study did not meet its primary endpoint of improvement in progression-free survival with Gazyva plus CHOP chemotherapy versus Rituxan plus CHOP chemotherapy.

International Lung Cancer Experts Seek Public Comments on Revised Molecular Testing Guideline to Improve Patient Selection and Targeted Therapies

6/28/2016 12:02 pm

(IASLC) June 28, 2016 - The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) announced today the open comment period for the revised evidence-based guideline, "Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors.”

Pelvic Exams May Not Prolong Life, a Task Force Says

6/28/2016 12:01 pm

(New York Times/Well blog) June 28, 2016 - Now an influential government task force says there isn’t evidence that routine pelvic exams are necessary or prolong a woman’s life. Some experts think they may even do more harm than good.

Bidens’ Cancer Moonshot Summit to Bring National Cancer Community Together

6/27/2016 11:05 am

(UNM CCC) June 24, 2016 - Vice President Biden and Dr. Jill Biden will host a Cancer Moonshot Summit in Washington, D.C. at the White House. Cheryl Willman, MD, Director and CEO of The University of New Mexico Comprehensive Cancer Center, will attend. At the same time, the UNM Comprehensive Cancer Center will host a local Cancer Moonshot Summit.

Astellas Suspended From UK Pharma Trade Group For ‘Deception On A Grand Scale’

6/27/2016 11:04 am

(STAT/Pharmalot) June 24, 2016 - In an unusual step, the pharmaceutical industry trade group in the United Kingdom has suspended Astellas for a year after discovering the drug maker disguised the true purpose of a meeting held for doctors, and then senior executives compounded the infraction by withholding crucial information when asked to explain the arrangements.

Testing After DCIS Needle Biopsies: $35 Million Boondoggle

6/27/2016 11:04 am

(Medscape Medical News) June 24, 2016 - Testing core needle biopsy specimens of ductal carcinoma in situ (DCIS) for hormone receptors is wasteful because testing is better done after surgery.

Government Agency Selects RCCA to Participate in Innovative "Oncology Care Model” Initiative

6/20/2016 12:02 pm

(New Jersey Online) June 20, 2016 - Regional Cancer Care Associates LLC, or RCCA, is one of a select group of oncology organizations nationwide invited by the Centers for Medicare and Medicaid Services (CMS) to participate in the agency's Oncology Care Model, or OCM.

National Cancer Moonshot Initiative Blue Ribbon Panel Hosted Special Session with the American Association for Cancer Research

6/10/2016 11:00 am

(AACR) June 9, 2016 - American Association for Cancer Research (AACR) President Nancy E. Davidson, MD, moderated a special session for AACR leaders, including young and early-stage investigators and minority researchers, with members of the National Cancer Institute (NCI) Blue Ribbon Panel last week to help inform the NCI’s scientific direction and goals in Vice President Joe Biden’s National Cancer Moonshot Initiative.

GlycoMimetics’ GMI-1271 Yields High Remission Rates and Favorable Tolerability in Phase 1 Portion of Phase 1/2 Clinical Trial for AML

6/10/2016 10:05 am

(GlycoMimetics) June 10, 2016 - GlycoMimetics, Inc. today announced data from the Phase 1 portion of its Phase 1/2 clinical trial of its novel E-selectin antagonist, GMI-1271, combined with induction chemotherapy, in patients with relapsed/refractory acute myeloid leukemia (AML). Dose escalation is complete and a GMI-1271 dose was identified for Phase 2 testing.

Sanofi Hopes to Oust Medivation's Board By August 1

6/9/2016 11:03 am

(Reuters) June 8, 2016 - Sanofi said on Wednesday it aims to remove the board of takeover target Medivation by Aug. 1 at the latest.

Medication Regimen May Lead to Less Hospital Time for Liver Cancer Patients

6/9/2016 11:01 am

(UC Academic Health Center) June 9, 2016 - Researchers at the University of Cincinnati College of Medicine have found that putting liver cancer patients on a medication regimen prior to undergoing a certain treatment could lead to shorter hospital stays and less chance for readmission due to complications.

Basilea Reports Presentation Of Data On Clinical Oncology Programs BAL101553 and BAL3833 at ASCO Meeting

6/9/2016 11:01 am

(Basilea Pharmaceutica) June 9, 2016 - Basilea Pharmaceutica Ltd. announced today that the final clinical data from the first-in-human phase 1/2a study with the intravenous (i.v.) form of its tumor checkpoint controller BAL101553 were presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, USA, on June 3-7, 2016.

Lung Cancer Breath ‘Signature’ Presents Promise for Earlier Diagnosis

6/9/2016 11:00 am

(Society of Thoracic Surgeons) June 9, 2016 - A single breath may be all it takes to identify the return of lung cancer after surgery, according to a study posted online today by The Annals of Thoracic Surgery.

Researchers Prove Lung Cancer Mutations Can Be Detected In Saliva

6/9/2016 11:00 am

(UCLA) June 8, 2016 - UCLA researchers’ findings could offer a non-invasive and more cost-effective method to detect lung cancer.

Minority BRCA-Positive Breast Cancer Survivors Appear Less Likely to Receive Preventive Surgery

6/6/2016 02:00 pm

(2016 ASCO Annual Meeting) June 6, 2016 - For breast cancer survivors who carry mutations in BRCA genes, preventive surgery can substantially reduce the risk of future breast and ovarian cancer.

Exelixis Announces Genentech Presentation of Preliminary Phase 1B Trial Results for the Combination of Cobimetinib and Atezolizumab at ASCO 2016 Annual Meeting

6/5/2016 06:19 pm

(Yahoo! Finance) June 5, 2016 - Exelixis, Inc. today announced that its collaborator Genentech, a member of the Roche Group, will present preliminary results from a phase 1b clinical trial evaluating the safety and clinical activity of cobimetinib, an Exelixis-discovered MEK inhibitor, in combination with atezolizumab, an anti-PD-L1 antibody discovered and developed by Genentech, in patients with metastatic colorectal cancer (CRC).

Genentech's Cancer Immunotherapy TECENTRIQ™ (Atezolizumab) Shrank Tumors in People with Previously Untreated Advanced Bladder Cancer

6/5/2016 06:07 pm

(Genentech) June 5, 2016 - Genentech, a member of the Roche Group, today announced that in a Phase II study, IMvigor 210, TECENTRIQ™ (atezolizumab) shrank tumors (objective response rate, ORR) in 24 percent (n=28) of people with locally advanced or metastatic urothelial carcinoma (mUC) who have not received a prior treatment (first-line) and who were ineligible for cisplatin-based chemotherapy.

Double Stem-Cell Transplant Improves Outcomes for Children with High-Risk Neuroblastoma

6/5/2016 06:00 pm

(2016 ASCO Annual Meeting) June 5, 2016 – A National Cancer Institute (NCI) funded phase III trial performed by the Children's Oncology Group found that adding a second autologous stem-cell transplant (ASCT, a transplant that uses the patient's own stem cells) to standard therapy improves outcomes for patients.

Vermont Law To Lessen Drug Price Increases Could Ultimately Lead To Higher Prices

6/4/2016 05:05 pm

(Forbes) June 3, 2016 - Some states are attempting to pass laws to gain control over drug price increases. Vermont Governor Peter Shumlin has just signed into law a bill to do just that.

Moffitt Cancer Center Finds Radiation Therapy with Pembrolizumab, Bevacizumab Safe for Recurrent High-Grade Glioma Patients

6/4/2016 05:02 pm

(Moffitt) June 4, 2016 - Patients with recurrent high-grade glioma brain tumors have few effective treatment options and the majority of available therapies do not improve survival. Moffitt Cancer Center will present preliminary results from a phase 1 study testing whether the addition of pembrolizumab to radiation therapy and bevacizumab is safe and can control tumor growth for these patients.

Adding Intraperitoneal Chemotherapy Slows Ovarian Cancer Progression

6/3/2016 02:00 pm

(ASCO Annual Meeting) June 3, 2016 - For some women with advanced ovarian cancer that was successfully treated surgically, delivering chemotherapy into the abdomen (intraperitoneal, or IP) as well as intravenously (IV) appears more effective than IV chemotherapy alone.

ASCO: Pembrolizumab Promising in Advanced Endometrial Cancer

6/3/2016 01:01 pm

(MedPage Today) June 2, 2016 - In a 24-patient phase Ib study of advanced endometrial tumors with PD-L1 expression, the PD-1 inhibitor pembrolizumab resulted in three patients (13%) achieving stable disease (95% CI 2.8-33.6, median duration 24.6 weeks), and three patients having a partial response (95% CI 2.8-33.6).

Senior NIH Doctors Protest Hospital Restructuring

6/2/2016 12:01 pm

(Wall Street Journal) June 1, 2016 - A high-level revolt is erupting among National Institutes of Health doctors who are disputing an outside panel’s assessment that an unsafe culture existed at the agency’s renowned hospital, and are protesting a shake-up of senior leadership based on the findings.

One in 5 Women With Ovarian Cancer Does Not Undergo Surgery, Penn Study Reveals

6/1/2016 12:00 pm

(Penn Medicine) June 1, 2016 - Nearly 20 percent of women with ovarian cancer do not undergo surgery, despite it being a standard part of treatment recommendations, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

Case Against the Part B Demo Outlined on Philadelphia Inquirer Blog

6/1/2016 11:05 am

(ASCO in Action) May 31, 2016 - As ASCO and other groups continue to urge The Centers for Medicare & Medicaid Services (CMS) to withdraw the agency's proposed Medicare Part B demonstration project, the controversy around the flawed experiment is making headlines around the country including in Diagnosis: Cancer--a new blog from the Philadelphia Inquirer and Philly.com--which recently posted an op-ed from ASCO President Julie M. Vose, MD, MBA, FASCO.

Drug Prices Too High? Sometimes, They’re Not Costly Enough

5/31/2016 12:00 pm

(New York Times/The Upshot blog) May 30, 2016 - For some of the most important drugs, the prices may be too low, giving rise to shortages.

Prostate Scan Agent Approved by FDA

5/31/2016 10:05 am

(MedPage Today) May 27, 2016 - The FDA approved the radioactive diagnostic agent fluciclovine (F-18, Axumin) for use with positron emission tomography (PET) to detect recurrent prostate cancer.

Genentech’s Gazyva® Showed Superior Progression-Free Survival Compared to Rituxan® in People with Previously Untreated Follicular Lymphoma

5/27/2016 06:51 am

(Genentech) May 26, 2016 - Phase III GALLIUM study met primary endpoint early, as determined by independent data monitoring committee.

Vermont Poised To Become First State To Require Pharma To Justify Pricing

5/23/2016 12:01 pm

(STAT/Pharmalot) May 19, 2016 - In less than a month, Vermont could become the first state in the country to require drug makers to justify price hikes on their medicines, a move that may prompt others to take similar action but also spark a battle with the pharmaceutical industry.