Eli Lilly & Co. (LLY)

Oncology Corporate Profile

Stock Performance

84.3600
0.6300

HQ Location

Lilly Corporate Center
Indianapolis, IN 46285

Company Description

Eli Lilly is a leading innovation-driven pharmaceutical corporation that is developing a growing portfolio of pharmaceutical products. Lilly's products treat cancer, depression, schizophrenia, attention-deficit hyperactivity disorder, diabetes, osteoporosis and many other conditions.

Website: http://www.lilly.com

Brand Generic Indication
Alimta®pemetrexedALIMTA® is a folate analog metabolic inhibitor indicated for:

• Locally Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer:

• Initial treatment in combination with cisplatin.

• Maintenance treatment of patients whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.

• After prior chemotherapy as a single-agent.

• Mesothelioma: in combination with cisplatin.

Limitations of Use:

• ALIMTA is not indicated for the treatment of patients with squamous cell non-small cell lung cancer.
Cyramza™ramucirumabCYRAMZA TM is a human vascular endothelial growth factor receptor 2 (VEGFR2) antagonist indicated for the
treatment of:

Gastric Cancer
•Advanced gastric cancer or gastro-esophageal junction adenocarcinoma, as a single - agent after prior fluoropyrimidine - or platinum - containing chemotherapy.

•Approved in combination with FOLFIRI (irinotecan, folinic acid, and 5-fluorouracil) chemotherapy to treat metastatic colorectal cancer (mCRC)

Erbitux®cetuximabErbitux® is an epidermal growth factor receptor (EGFR) antagonist indicated for
treatment of:

Head and Neck Cancer
• Locally or regionally advanced squamous cell carcinoma of the head and neck in combination with radiation therapy.
• Recurrent locoregional disease or metastatic squamous cell carcinoma of the head and neck in combination with platinum-based therapy with 5-FU.
• Recurrent or metastatic squamous cell carcinoma of the head and neck
progressing after platinum-based therapy.

Colorectal Cancer
K-Ras mutation-negative (wild-type), EGFR-expressing, metastatic colorectal cancer as determined by FDA-approved tests
• in combination with FOLFIRI for first-line treatment
• in combination with irinotecan in patients who are refractory to irinotecan-based chemotherapy,
• as a single agent in patients who have failed oxaliplatin- and irinotecan-based chemotherapy or who are intolerant to irinotecan.

Limitation of Use: Erbitux (cetuximab) is not indicated for treatment of K-Ras
mutation-positive colorectal cancer.
Gemzar®gemcitabine hydrochlorideOvarian Cancer — Gemzar in combination with carboplatin is indicated for the treatment of patients with advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy.

Breast Cancer — Gemzar in combination with paclitaxel is indicated for the first-line treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing adjuvant chemotherapy, unless anthracyclines were clinically contraindicated.

Non-Small Cell Lung Cancer — Gemzar is indicated in combination with cisplatin for the first-line treatment of patients with inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer.
Pancreatic Cancer — Gemzar is indicated as first-line treatment for patients with locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas. Gemzar is indicated for patients previously treated with 5-FU.
Portrazza™ necitumumabPORTRAZZA™ is an epidermal growth factor receptor (EGFR) antagonist indicated, in combination with gemcitabine and cisplatin, for first-line treatment of patients with metastatic squamous non - small cell lung cancer.

View additional information on commercial products here »

  • Brand
  • Generic
  • Investigational
Brand / Product Class Area of Study Phase Partnership
abemaciclibCDK 4/6 inhibitorBreast cancerIII
arzoxifeneselective estrogen receptor modulator (SERM)Breast cancerIII
enzastaurinserine/therenine kinase inhibitorDiffuse large B-cell Lymphoma (DLBCL)III
abemaciclibCDK 4/6 inhibitorNon Small Cell Lung Cancer (NSCLC)III
Alimta? / pemetrexed (+ pembrolizumab)antimetabolite (a folic acid antagonist)Non Small Cell Lung Cancer (NSCLC)IIIMerck
Alimta? / pemetrexedantimetabolite (a folic acid antagonist)Non Small Cell Lung Cancer (NSCLC)IIIAlmac Diagnostics
Alimta? / pemetrexed (+ cisplatin)antimetabolite (a folic acid antagonist)Recurrent or metastatic Head & Neck cancer (squamous)IIIAlmac Diagnostics
Cyramza? / ramucirumab / IMC-1121Banti-VEGFR-2 monoclonal antibody1st line metastatic Colorectal cancerIII
Cyramza? / ramucirumab / IMC-1121Banti-VEGFR-2 monoclonal antibody1st line metastatic Hepatocellular carcinoma (HCC)III
Cyramza? / ramucirumab / IMC-1121Banti-VEGFR-2 monoclonal antibody2nd line metastatic Breast cancerIII
Cyramza? / ramucirumab (+ paclitaxel) / IMC-1121Banti-VEGFR-2 monoclonal antibodyGastric cancerIII
Cyramza? / ramucirumab / IMC-1121Banti-VEGFR-2 monoclonal antibodyNon Small Cell Lung Cancer (NSCLC)III
Erbitux? / cetuximabanti-EGFR monoclonal antibody1st line metastatic Colorectal cancerIIIBristol-Myers Squibb
Erbitux? / cetuximabanti-EGFR monoclonal antibody1st line metastatic Non Small Cell Lung Cancer (NSCLC)IIIBristol-Myers Squibb
Erbitux? / cetuximabanti-EGFR monoclonal antibody2nd line metastatic Non Small Cell Lung Cancer (NSCLC)IIIBristol-Myers Squibb
cyramzaanti-VEGFR-2 monoclonal antibodyBladder cancerII
IMC-3G3anti-platelet derived growth factor receptor alpha (PDGFR(alpha)) monoclonal antibody (humanized)Breast cancerII
icrucumab / LY3012212 IgG1 monoclonal antibodyBreast cancerII
LY2606368CHK1 inibitorBreast cancerII
galunisertib / LY2157299kinase inhibitorGlioblastoma Multiforme (GBM)II
galunisertib / LY2157299kinase inhibitorHepatocellular carcinoma (HCC)II
LY2835219CDK inhibitorMantle Cell Lymphoma (MCL)II
LY2603618CHK1 inibitorNon Small Cell Lung Cancer (NSCLC)II
IMC-3G3anti-platelet derived growth factor receptor alpha (PDGFR(alpha)) monoclonal antibody (humanized)Ovarian cancerII
IMC-3G3anti-platelet derived growth factor receptor alpha (PDGFR(alpha)) monoclonal antibody (humanized)Prostate cancerII
LY2510924CXCR4 peptide inhibitorRenal cell carcinoma (RCC)II
LY2510924CXCR4 peptide inhibitorSmall Cell Lung Cancer (SCLC)II
LY2940680hedgehog/SMO antagonistSmall Cell Lung Cancer (SCLC)II
LY2801653c-Met inhibitorVarious cancer typesII
LY2874455FGF receptor inhibitorVarious cancer typesII
LY2875358humanized IgG4 monoclonal antibodyVarious cancer typesII
LY2090314GSK3 inhibitorVarious cancer typesII
IMC-A12insulin-like growth factor-1 receptor (IGF-1R) inhibitor (humanized monoclonal antibody)Various cancer typesII
Cyramza? / ramucirumab / IMC-1121Banti-VEGFR-2 monoclonal antibody1st line metastatic MelanomaII
Cyramza? / ramucirumab (+ apecitabine) / IMC-1121Banti-VEGFR-2 monoclonal antibody2nd line metastatic Breast cancerII
IMC-18F1anti-VEGFR-1 monoclonal antibody (humanized)Breast cancerI
IMC-18F1anti-VEGFR-1 monoclonal antibody (humanized)Colorectal cancerI
tabalumab / LY2127399 (+ bortezomib)BAFF antibodyGastric cancerIMillennium
LY2157299 (+ IMCgp100 )immunotherapyMelanomaIImmunocore
LY2801653 (+ IMCgp100)immunotherapyMelanomaIImmunocore
AME133vanti-CD20 monoclonal antibodyNon-Hodgkin's Lymphoma (NHL)I
gemcitabine prodrugantimetabolite (pyrimidine analog)Various cancer typesI
IMC-3C5IgG1 monoclonal antibody (humanized)Various cancer typesICircadian Technologies
Unnamedanti-VEGFR-3 monoclonal antibodyVarious cancer typesI
Unnamednotch inhibitorVarious cancer typesI
UnnamedCSF-1R monoclonal antibodyVarious cancer typesI
Unnamedp7056 kinase/AKT dual inhibitorVarious cancer typesI
UnnamedPan-Raf kinase inhibitorVarious cancer typesI
UnnamedP13 kinase/mTOR dual inhibitorVarious cancer typesI
Cyramza? / ramucirumab / IMC-1121Banti-VEGFR-2 monoclonal antibodyGastric cancerApproved
TGF-BR2monoclonal antibodyVarious cancer typesI
LY2228820p38 MAP kinase inhibitor)Ovarian cancerII
Unnamedfibroblast growth factor receptor 1 (FGFR1) antagonistVarious cancer typesPreclinical
Unnamedneuropilin monoclonal antibodyVarious cancer typesPreclinical

View additional information on product candidates here »

Source


http://www.lilly.com

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FDA Approves ERBITUX(R) (cetuximab) as First-Line Treatment in KRAS Mutation-Negative (Wild-Type) Epidermal Growth Factor Receptor (EGFR)-Expressing Metastatic Colorectal Cancer in Combination with FOLFIRI (Irinotecan, 5-Fluorouracil, Leuco

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[Business Wire] - Eli Lilly and Company and Bristol-Myers Squibb Company today announced that ERBITUX® in combination with the chemotherapy regimen FOLFIRI has been granted full approval by the U.S.

Strengthening the Portfolio

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[PR Newswire] - INDIANAPOLIS, July 6, 2012 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) announced today that it has met the United States Food and Drug Administration (FDA) requirements for pediatric exclusivity ...

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