Plexxikon Inc. (Plexxikon)

Oncology Corporate Profile

HQ Location

91 Bolivar Drive
Berkeley, CA 94710

Company Description

Plexxikon is a leader in the discovery and development of novel, small molecule pharmaceuticals. The company has utilized its proprietary discovery platform to successfully develop a portfolio of competitively differentiated clinical and preclinical stage programs in a number of therapeutic areas and disease indications. Plexxikon’s platform enables the design of highly selective and targeted medicines, supporting the company’s broader strategy to develop personalized medicines. With its Scaffold-Based Drug Discovery Platform™, Plexxikon uses compound and target structural data to guide chemistry early in the drug lead generation process in conjunction with a highly specialized scaffold-like screening library, to design new drug candidates within various families of drug targets. This systematic, cost-efficient approach allows Plexxikon to leverage its target-specific chemistry investment for multiple targets within a given family. Additionally, Plexxikon’s platform has proven particularly amenable to the design of highly selective inhibitors. This selectivity has enhanced the safety profile of its targeted drugs. In April 2011, Plexxikon became a member of the Daiichi Sankyo Group, and continues to build its broad and diverse pipeline


This company does not have any commercial products
  • Brand
  • Generic
  • Investigational
Brand / Product Class Area of Study Phase Partnership
Zelboraf? (+ Yervoy?) / vemurafenib (+ ipilimumab) / PLX4032 (RG7204) BRAF-selective kinase inhibitorAdjuvant melanomaIIIGenentech / Roche
PLX3397CSF1 inhibitorAcute Myelogenous Leukemia (AML)II
PLX3397CSF1 inhibitorBreast cancerII
PLX3397CSF1 inhibitorGlioblastoma Multiforme (GBM)II
PLX3397CSF1 inhibitorHodgkin's LymphomaII
PLX3397CSF1 inhibitorProstate cancerII
Zelboraf? / vemurafenib / PLX4032 (RG7204) BRAF-selective kinase inhibitorThyroid cancerIGenentech / Roche

View additional information on product candidates here »

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