Video Center


The OBR Video Center Features educational videos covering a wide range of oncology specific topics.

Neelima Denduluri, MD, regarding the implications of the TAILORx study from ASCO 2018

Dr. Denduluri elaborates on the implications of the TAILORx study presented at the 2018 ASCO Annual Meeting

Published: 25 June 2018

Recent Videos: Breast

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Sara M. Tolaney, MD, MPH, provides an overview of the results from the SOPHIA trial

Dr. Tolaney, Associate Director, Susan F. Smith Center for Women's Cancers, Director, Clinical Trials, Breast Oncology, Senior Physician, Assistant Professor ...

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Debu Tripathy, MD, elaborates on the SOPHIA trial in HER+ metastatic breast cancer

Dr. Tripathy, Professor and Chair, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, tell us ...

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Debu Tripathy, MD, regarding CDK 4/6 inhibitors in the treatment of breast cancer

Dr. Tripathy, Professor and Chair, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, tells us ...

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Debu Tripathy, MD, elaborates on outcomes from the ImPassion130 trial

Dr. Tripathy, Professor and Chair, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, tells us ...

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Debu Tripathy, MD, shares the outcomes of the MONALEESA-7 in premenopausal metastatic breast cancer

Dr. Tripathy, Professor and Chair, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, shares the ...

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Sara M. Tolaney, MD, MPH, on the efficacy & safety of combination eribulin + pembrolizumab

Dr. Tolaney, Associate Director, Susan F. Smith Center for Women's Cancers, Director, Clinical Trials, Breast Oncology, Senior Physician, Assistant Professor ...

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Debra Patt, MD, MPH, MBA, considers the role of CDK 4/6 inhibitors in advanced breast cancer

Dr. Patt, Executive Vice President, Policy, Academic Programs, Strategic Initiatives, Texas Oncology, considers the role of CDK 4/6 inhibitors in ...

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Sara M. Tolaney, MD, MPH, shares outcomes from the ImPassion130 study in TNBC

Dr. Tolaney, Associate Director, Susan F. Smith Center for Women's Cancers, Director, Clinical Trials, Breast Oncology, Senior Physician, Assistant Professor ...

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Debra Patt, MD, MPH, MBA, regarding the implications of the ImPassion130 trial in TNBC

Dr. Patt, Executive Vice President, Policy, Academic Programs, Strategic Initiatives, Texas Oncology, tells us about the monumental results of the ...

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Sara M. Tolaney, MD, MPH, shares outcomes from the MONALEESA-7 trial

Associate Director, Susan F. Smith Center for Women's Cancers, Director, Clinical Trials, Breast Oncology, Senior Physician, Assistant Professor of Medicine, ...

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Sara M. Tolaney, MD, MPH, provides an overview of the results from the SOPHIA trial

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Debu Tripathy, MD, elaborates on the SOPHIA trial in HER+ metastatic breast cancer

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Debu Tripathy, MD, regarding CDK 4/6 inhibitors in the treatment of breast cancer

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Debu Tripathy, MD, elaborates on outcomes from the ImPassion130 trial

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Debu Tripathy, MD, shares the outcomes of the MONALEESA-7 in premenopausal metastatic breast cancer

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Sara M. Tolaney, MD, MPH, on the efficacy & safety of combination eribulin + pembrolizumab

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Debra Patt, MD, MPH, MBA, considers the role of CDK 4/6 inhibitors in advanced breast cancer

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Sara M. Tolaney, MD, MPH, shares outcomes from the ImPassion130 study in TNBC

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Debra Patt, MD, MPH, MBA, regarding the implications of the ImPassion130 trial in TNBC

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Sara M. Tolaney, MD, MPH, shares outcomes from the MONALEESA-7 trial

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Debra Patt, MD, MPH, MBA, on the important implications of the MONALEESA-7 trial

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Neelima Denduluri, MD, elaborates on the SOPHIA trial data in HER+ metastatic breast cancer

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Neelima Denduluri, MD, regarding the EMBRACA trial in HER2- metastatic breast cancer

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Neelima Denduluri, MD, discusses outcomes from the ImPassion130 trial

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Neelima Denduluri, MD, regarding the MONALEESA-7 trial in premenopausal metastatic breast cancer

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Howard A. "Skip" Burris III, MD, FACP, FASCO, comments on the TAILORx study from ASCO 2018

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Howard A. "Skip" Burris III, MD, FACP, FASCO, on the outcomes of the PERSEPHONE clinical trial

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Neelima Denduluri, MD, on the outcomes of the SANDPIPER study presented at ASCO 2018

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Neelima Denduluri, MD, looks back on the Short-HER trial from the 2017 ASCO Annual Meeting

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Neelima Denduluri, MD, offers opinion on the PERSEPHONE trial in early HER2+ breast cancer

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Neelima Denduluri, MD, tells us about the recent updates to breast cancer guidelines

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Neelima Denduluri, MD, comments on the role of CDK4/6 inhibitors

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Che-Kai Tsao, MD, elaborates on results from the TITAN study in mCRPC from ASCO '19

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Sandip Patel, MD, on treatment in the 2nd line setting following PD-L1 targeting agents

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Sandip Patel, MD, speculates on the impact of the RELAY trial presented at ASCO 2019

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Che-Kai Tsao, MD, offers opinion on the results of the ENZAMET study in mHSPC

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Che-Kai Tsao, MD, discusses the current application of biomarkers in renal cell carcinoma

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Saad Usmani, MD, FACP, considers data in smoldering MM coming out of ASCO 2019

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Parameswaran Hari, MD, speculates on whether KRD will replace stem cell transplant

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Tomasz M. Beer MD, FACP, outlines results from Keynote-365 presented at ASCO 2019

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Shirish Madhav Gadgeel, MBBS, on treating patients who have already received PD-L1 targeting agents

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Che-Kai Tsao, MD, on deciding between I-O + TKIs combinations indicated for the treatment of RCC

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Philip Philip MD, PhD, FRCP, on the APACT trial in surgically resected pancreatic adenocarcinoma

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Sandip Patel, MD, describes the ideal patient to receive Alimta + Keytruda based on Keynote-189

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Lowell L. Hart, MD, FACP, explains the mechanism of action for trilaciclib

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Parameswaran Hari, MD, discusses the role of CAR-T therapy in multiple myeloma

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Shirish Madhav Gadgeel, MBBS, offers opinion on the results of the RELAY trial from ASCO 2019

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Josep Tabernero, MD, PhD, speculates on exciting clinical trial outcomes in gastric cancer

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Tomasz M. Beer MD, FACP, considers the role of metformin in castrate-resistant prostate cancer

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Michael B. Atkins, MD, regarding the long-term follow up of Checkmate-004 in metastatic melanoma

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Lowell L. Hart, MD, FACP, regarding recent data investigating trilaciclib in SCLC

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Parameswaran Hari, MD, considers whether isatuximab will become a viable option in MM

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Shirish Madhav Gadgeel, MBBS, on the ideal patient to receive Alimta + Keytruda based on Keynote-189

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Robert A. Figlin, MD, speculates on clinical advances in renal cell carcinoma

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Marwan G. Fakih, MD, on combining regorafenib + checkpoint inhibition in advanced CRC

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Nancy A. Dawson, MD, regarding preferred agents in the 2nd line setting in renal cell carcinoma

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Paul M. Barr, MD, considers the role of CAR-T therapy in B-cell lymphomas

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Michael B. Atkins, MD, on the role of IMDC classification in treatment decision-making

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Tomasz M. Beer MD, FACP, on the efficacy of abiraterone + enzalutamide in mCRPC

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Robert A. Figlin, MD, regarding the role of systemic therapy in oligometastatic RCC

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Marwan G. Fakih, MD, on whether KRAS amplification predicts resistance to EGFR therapies

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Nancy A. Dawson, MD, on selecting the appropriate I-O + TKI combo in the treatment of 1st line RCC

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Vincent Chung, MD, shares details from the APACT study in pancreatic adenocarcinoma

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Tomasz M. Beer MD, FACP, discusses outcomes from the TITAN study in mCSPC

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Paul M. Barr, MD, elaborates on outcomes from the RESONATE trial in relapsed/refractory CLL

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Michael B. Atkins, MD, comments on clinical trials investigating the use of I-O and TKIs in RCC

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Saad Usmani, MD, FACP, regarding outcomes from the MAIA study presented at ASCO 2019

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Che-Kai Tsao, MD, considers the various I-O and TKI combinations available for 1st line RCC

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Josep Tabernero, MD, PhD, provides perspective on the POLO trial in pancreatic

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Philip Philip MD, PhD, FRCP, on BRCA gene mutations & outcomes in pancreatic cancer

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Sandip Patel, MD, on treating non-squamous NSCLC patients expressing high levels of PD-L1

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Kristin Higgins, MD, offers opinion on the PACIFIC study in non-small cell lung cancer

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Parameswaran Hari, MD, considers the implications of the CASSIOPEIA trial

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Marwan G. Fakih, MD, regarding outcomes from the AMG 510 study

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Shirish Madhav Gadgeel, MBBS, on treating non-squamous NSCLC patients expressing high PD-L1

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Robert A. Figlin, MD, on I-O & TKIs available and indicated for the treatment of 2nd line RCC

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Marwan G. Fakih, MD, on why AMG 510 seems promising in colorectal and lung cancers

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Nancy A. Dawson, MD, discusses outcomes from the TITAN study in mCSPC

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Vincent Chung, MD, elaborates on BRCA mutations and pancreatic cancer

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Tomasz M. Beer MD, FACP, tells us about the ENZAMET study in mHSPC

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Paul M. Barr, MD, on data from the CLL-14 trial in chronic lymphocytic leukemia

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Michael B. Atkins, MD, considers preferred agents in the treatment of RCC in the 2nd line

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Saad Usmani, MD, FACP, compares IV daratumumab and subcutaneous daratumumab

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Che-Kai Tsao, MD, regarding the evolving landscape of metastatic clear cell RCC

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Josep Tabernero, MD, PhD, offers perspective on Keynote-062 in advanced gastroesophageal

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Philip Philip MD, PhD, FRCP, discusses outcomes from the POLO trial in pancreatic cancer

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Sandip Patel, MD, comments on the top stories in lung cancer from ASCO 2019

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Kristin Higgins, MD, shares her interpretation of the PACIFIC study in unresectable NSCLC

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Parameswaran Hari, MD, elaborates on the outcome from the ECOG trial in SMM

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Shirish Madhav Gadgeel, MBBS, regarding the top stories in lung cancer from ASCO 2019

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Robert A. Figlin, MD, considers combination I-O and TKIs indicated for the treatment of 1st line RCC

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Marwan G. Fakih, MD, describes the role of KRAS inhibitors in colorectal cancer

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Nancy A. Dawson, MD, regarding the ENZAMET study in mHSPC presented at ASCO '19

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Vincent Chung, MD, shares outcomes from the POLO trial metastatic pancreatic cancer

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Paul M. Barr, MD, offers opinion on ibrutinib in 1st line chronic lymphocytic leukemia

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Michael B. Atkins, MD, on selecting I-O and TKI combinations for the treatment of 1st line RCC

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Andre Goy, MD, explains how lenalidomide will impact the management of FL and MZL

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Leonard Saltz, MD, offers opinion on the value of of liquid biopsy in colorectal cancer treatment

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Andre Goy, MD, discusses the role of CAR-T therapy in lymphomas

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Robert M. Rifkin, MD, FACP, speculates on the promise of bispecific antibodies in MM

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Andre Goy, MD, shares the most exciting advances in lymphoma coming out of ASCO 2019

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Debra Patt, MD, MPH, MBA, outlines policies proposed to address drug pricing

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Leonard Saltz, MD, offers opinion on molecular profiling in the treatment of CRC

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Robert M. Rifkin, MD, FACP, discusses maintenance regimens for multiple myeloma

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Debra Patt, MD, MPH, MBA, considers the transition from volume to value in the oncology space

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Thomas A. Abrams, MD, outlines next steps if an HCC patient fails 1st line therapy with I-O

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Paul G. Richardson, MD, shares clinical results from the ECOG trial in smoldering MM

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Debra Patt, MD, MPH, MBA, on the factors influencing cost in novel therapeutic interventions

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Leonard Saltz, MD, shares outcomes from the APACT trial in pancreatic adenocarcinoma

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Robert M. Rifkin, MD, FACP, considers progression-free survival in MM when treating with isatuximab

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Paul G. Richardson, MD, considers whether isatuximab shows promise as a treatment option for MM

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Talia Golan, MD, explains the role of biomarkers in the treatment of pancreatic cancer

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Thomas A. Abrams, MD, offers thoughts on Keynote-062 in gastric/gastroesophageal cancer

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Leonard Saltz, MD, considers the complexities of managing metastatic colorectal cancer

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Robert M. Rifkin, MD, FACP, explains how isatuximab differs from daratumumab

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Paul G. Richardson, MD, considers progression-free survival in MM when treating with isatuximab

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Talia Golan, MD, regarding the practice-changing potential of the POLO trial

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Thomas A. Abrams, MD, elaborates on the outcomes from the APACT study

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Leonard Saltz, MD, on whether data presented at ASCO '19 will change the way we treat CRC

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Robert M. Rifkin, MD, FACP, discusses outcomes from the ECOG trial in smoldering multiple myeloma

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Paul G. Richardson, MD, regarding the updated FORTE trial data in multiple myeloma

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Talia Golan, MD, elaborates on the outcomes from the POLO study presented at ASCO 2019

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Thomas A. Abrams, MD, provides perspective on the POLO trial in metastatic pancreatic cancer

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Naiyer Rizvi, MD, speculates on the future of drug development in NSCLC

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William Oh, MD, tells us about the results of Keynote-365 in mCRPC

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Naiyer Rizvi, MD, offers thoughts on the role of blood TMB vs. tissue TMB

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William Oh, MD, speculates on upcoming prostate cancer PARP inhibitor trials

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Daniel J. DeAngelo, MD, PhD, comments on how to manage MDS patients ineligible for transplant

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Naiyer Rizvi, MD, describes the role of PD-L1 & TMB biomarkers in the treatment of lung cancer

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William Oh, MD, considers the role of biomarker selection trials in prostate cancer

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Andrew Goy, MD, explains how the approval of lenalidomide will impact the management of FL & MZL

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Daniel J. DeAngelo, MD, PhD, considers the implications of the recent wave of approvals in AML

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Naiyer Rizvi, MD, tells us about the results of Keynote-001 in NSCLC

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William Oh, MD, shares the differences between the ENZAMET and TITAN studies

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Andrew Goy, MD, discusses the role of CAR-T therapy in lymphomas

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Daniel J. DeAngelo, MD, PhD, on the significance of the updated data for gilteritinib in AML

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Naiyer Rizvi, MD, explains the role of biomarkers in lung cancer treatment planning

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William Oh, MD, discusses outcomes from the TITAN study in mCSPC

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Andrew Goy, MD, elaborates on the most exciting recent clinical advances in lymphoma

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Daniel J. DeAngelo, MD, PhD, on the latest data involving uproleselan with chemotherapy in AML

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Bradley McGregor, MD, considers strategies for treating 2nd line RCC patients

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Ravi Salgia, MD, PhD, considers the unmet medical needs in the treatment of NSCLC

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Ravi Salgia, MD, PhD, on treatment in the 2nd line setting after 1st line PD-L1 targeting agents

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Ravi Salgia, MD, PhD, on the ideal patient to receive Alimta plus Keytruda based on Keynote-189

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Lori A. Leslie, MD, on the recent data regarding umbralisib in relapsed/refractory lymphoma

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Lori A. Leslie, MD, speculates on how CAR-T cell therapy may be combined to treat lymphomas

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Tian Zhang, MD, on the evolving landscape of metastatic hormone-sensitive prostate cancer

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Ravi Salgia, MD, PhD, on treating non-squamous, NSCLC patients with high levels of PD-L1

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Tian Zhang, MD, discusses the most anticipated trial results regarding biomarkers in RCC

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Ravi Salgia, MD, PhD, offers strategies for identifying PD-L1 status

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Danny Rischin, MD, MBBS, FRACP, shares updated data from ASCO '19 investigating cemiplimab in cSCC

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Tian Zhang, MD, regarding strategies for treating RCC in the 2nd line setting

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Ravi Salgia, MD, PhD, outlines some of the molecular tests utilized prior to treating advanced NSCLC

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Danny Rischin, MD, MBBS, FRACP, on the importance of the stratification by PD-L1 score

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Tian Zhang, MD, offers perspective on treating newly diagnosed RCC patients

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Ravi Salgia, MD, PhD, comments on germline mutations & the impact on NSCLC patients

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Danny Rischin, MD, MBBS, FRACP, shares thoughts on Keynote-048 presented at ASCO 2019

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Bradley McGregor, MD, considers the optimal approach to treating newly diagnosed RCC patients

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Richard S. Finn, MD, speculates on the next phase of HCC management and research

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Imane El Dika, MD, outlines next steps if an HCC patient fails 1st line therapy

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Edward B. Garon, MD, on the implications of Keynote-189

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Richard S. Finn, MD, outlines the next steps if an HCC patient fails 1st line therapy

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Imane El Dika, MD, considers the role of I-O in the management of HCC

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Edward B. Garon, MD, elaborates on the role of PD-L1 in the management of lung cancer

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Richard S. Finn, MD, offers opinion on the broader role of I-O in the management of HCC

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Imane El Dika, MD, elaborates on the outcomes of Keynote-240 presented at ASCO 2019

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Edward B. Garon, MD, considers the implications of Keynote-001 in advanced NSCLC

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Richard S. Finn, MD, regarding outcomes from Keynote-240 in 1st line HCC

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Pasi A. Jänne, MD, PhD, regarding the unmet medical needs in the treatment of NSCLC

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Daneng Li, MD, elaborates on the COSMIC-312 trial in hepatocellular carcinoma

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Pasi A. Jänne, MD, PhD, discusses some of the challenges in managing NSCLC

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Martin E. Gutierrez, MD, discusses some of the top challenges in managing NSCLC

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Daneng Li, MD, describes next steps if an HCC patient fails 1st line I-O therapy

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Bruce Feinberg, DO, speculates on the future of AI in oncology treatment centers

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Amrita Krishnan, MD, considers whether KRD will replace stem cell transplant

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Pasi A. Jänne, MD, PhD, on treating patients in the 2nd line setting after 1st line Keytruda

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Martin E. Gutierrez, MD, on 2nd line treatment options following 1st line PD-L1 targeting agents

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Bruce Feinberg, DO, outlines some of the concerns that oncologists have regarding AI

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Lori A. Leslie, MD, elaborates on recent outcomes from the CLL14 trial

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Amrita Krishnan, MD, discusses the future of isatuximab in the treatment of relapsed/refractory MM

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Pasi A. Jänne, MD, PhD, elaborates on outcomes from the RELAY trial

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Martin E. Gutierrez, MD, discusses the implications of the RELAY trial from ASCO 2019

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Bruce Feinberg, DO, on how AI may evolve as a clinical decision-making support tool

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Amrita Krishnan, MD, regarding outcomes from the CASSIOPEIA trial presented at ASCO '19

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Pasi A. Jänne, MD, PhD, on treating non-squamous NSCLC patients expressing high levels of PD-L1

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Martin E. Gutierrez, MD, regarding the implications of the initial & updated results of Keynote-189

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Bruce Feinberg, DO, on real-world examples of artificial intelligence applications in oncology

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Kim Chi, MD, speculates on upcoming prostate cancer PARP inhibitor trials

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Amrita Krishnan, MD, tells us about the outcomes of the ECOG trial in SMM

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Kim Chi, MD, provides perspective on biomarker selection trials in prostate cancer

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Daneng Li, MD, considers the role of immuno-oncology in the management of HCC

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Pasi A. Jänne, MD, PhD, on molecular testing prior to the treatment of advanced NSCLC

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Martin E. Gutierrez, MD, on treating non-squamous NSCLC patients expressing high levels of PD-L1

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Bruce Feinberg, DO, defines and considers artificial intelligence as a healthcare tool

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Pasi A. Jänne, MD, PhD, on the study of U3-1402 in EGFR mutant NSCLC presented at ASCO 2019

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Daneng Li, MD, tells us about the outcomes of Keynote 240 presented at ASCO 2019

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Bradley McGregor, MD, on combo ipilimumab + nivolumab in variant histologies of bladder cancer

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Lori A. Leslie, MD, on how CAR-T cell therapy has impacted the treatment of B-cell lymphomas

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Kim Chi, MD, regarding the differences in design between the ENZAMET & TITAN studies

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Tian Zhang, MD, on promising studies in sarcomatoid RCC & urothelial cancer from ASCO '19

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Martin E. Gutierrez, MD, on the role of clinico-genomic data sharing in lung cancer treatment

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Pasi A. Jänne, MD, PhD, on advances in the treatment of lung cancer being presented at ASCO 2019

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Ravi Salgia, MD, PhD, offers opinion on the top challenges in managing NSCLC

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Bruce Feinberg, DO, considers how artificial intelligence may help practices become more efficient

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Tian Zhang, MD, shares thoughts on the PDIGREE trial in metastatic, untreated RCC

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Bradley McGregor, MD, on the data regarding enfortumab in post-platinum + I-O bladder cancer

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Kim Chi, MD, regarding the TITAN study presented at ASCO 2019

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Will Tomorrow's CAR-T Therapy Innovations Solve Today's Challenges?

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How Can Manufacturers Help Institutions Prepare for CAR-T Therapies?

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How Can a CAR-T Center Get Established and Effectively Treat Patients?

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Sai-Hong Ignatius Ou, MD, PhD, comments on Tumor Mutation Burden (TMB) as a biomarker in NSCLC

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Sai-Hong Ignatius Ou, MD, PhD, on pemetrexed maintenance therapy

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Sai-Hong Ignatius Ou, MD, PhD, discusses key takeaways from the IMpower150 study at ASCO 2018

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Sai-Hong Ignatius Ou, MD, PhD, comments on combo chemotherapy & immunotherapy in 2nd line NSCLC

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Sai-Hong Ignatius Ou, MD, PhD, regarding combo chemotherapy & immunotherapy in 1st line NSCLC

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Sai-Hong Ignatius Ou, MD, PhD, on testing for PD-L1 expression in NSCLC

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Benjamin Philip Levy, MD, on Tumor Mutation Burden (TMB) as a biomarker in NSCLC

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Benjamin Philip Levy, MD, on maintenance therapy following carboplatin, pemetrexed & pembrolizumab

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Benjamin Philip Levy, MD, comments on the IMpower150 clinical trial in NSCLC

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Benjamin Philip Levy, MD, on options for NSCLC patients who progress on 1st line I-O & chemotherapy

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Benjamin Philip Levy, MD, regarding combo chemotherapy & immunotherapy in 2nd line NSCLC

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Benjamin Philip Levy, MD, discusses the practice-changing outcomes from Keynote 189

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Benjamin Philip Levy, MD, offers opinion on testing for PD-L1 expression in NSCLC

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Novel Endpoints: Working Through Today's Challenges to Improve the Future of Cancer Care

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Novel Endpoints in Cancer Care: What Lies Ahead

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Oncology Clinical Trials: Why We're Searching for Emerging Endpoints

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Howard (Jack) West, MD, regarding Tumor Mutation Burden (TMB) as a biomarker for NSCLC patients

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Howard (Jack) West, MD, on maintenance therapy after carboplatin, pemetrexed & pembrolizimab

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NGS and Cancer: Combatting the Hazards of Misinformation

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Will NGS-Based Cancer Tests Become Routine?

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Next-Gen Sequencing is Transforming Oncology Practices

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Howard (Jack) West, MD, discusses key takeaways from the IMpower150 study in NSCLC

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Howard (Jack) West, MD, on treatment options for patients who progress on I-O & chemotherapy

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Howard (Jack) West, MD, regarding the combination of immunotherapy & chemotherapy in NSCLC

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Howard (Jack) West, MD, regarding PDL-1 expression and NSCLC

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Howard A. "Skip" Burris III, MD, FACP, FASCO, considers predictive biomarkers in NSCLC

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Howard A. "Skip" Burris III, MD, FACP, FASCO, regarding novel concepts in clinical trial design

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Howard A. "Skip" Burris III, MD, FACP, FASCO, shares his goals for the 2019 ASCO Annual Meeting

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Robert A. Figlin, MD, on the convenience factor of oral TKIs & treatment decisions in advanced RCC

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Robert A. Figlin, MD, on the trade-offs between safety & efficacy when discussing 1st line RCC

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Robert A. Figlin, MD, provides perspective on I-O failures

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Robert A. Figlin, MD, on deciding which metastatic RCC patients should get a TKI as 1st line therapy

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Robert A. Figlin, MD, on how checkpoint inhibitors figure into treatment for 1st line RCC patients

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Walter Stadler, MD, on therapies for high-volume, metastatic castration-resistant prostate cancer

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Walter Stadler, MD, on immunotherapy and prostate cancer treatment algorithms

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Walter Stadler, MD, comments on the PROSPER & SPARTAN studies in prostate cancer

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Walter Stadler, MD, regarding TKIs in the treatment of renal cell carcinoma

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Walter Stadler, MD, on treating RCC in the 2nd line setting following I-O failure

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Walter Stadler, MD, considers which mRCC patients should receive a TKI as 1st line therapy