Video Center


The OBR Video Center Features educational videos covering a wide range of oncology specific topics.

Scott Kopetz, MD, explains how BRAF mutations figure into treatment algorithms for CRC

Dr. Kopetz, Professor, GI Medical Oncology, MD Anderson Cancer Center, explains how BRAF mutations figure into treatment algorithms for colorectal cancer (CRC)

Tags: ColorectalESMO 2019

Published: 11 October 2019

Recent Videos: Colorectal

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Scott Kopetz, MD, explains how BRAF mutations figure into treatment algorithms for CRC

Dr. Kopetz, Professor, GI Medical Oncology, MD Anderson Cancer Center, explains how BRAF mutations figure into treatment algorithms for colorectal ...

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Stefan Kasper, MD, provides updates on the BEACON trial in BRAF-mutant CRC

Dr. Kasper, Professor of Oncology, University Hospital West German Cancer Center, Essen, provides updates on the phase III BEACON trial ...

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Deborah Shrag, MD, MPH, on which biomarkers are important in the diagnosis & management of CRC

Dr. Shrag, Professor of Medicine, Harvard Medical School, Chief, Division of Population Sciences, Medical Oncology, Dana-Farber Cancer Institute, provides opinion ...

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Scott Kopetz, MD, shares updates from the BEACON trial in BRAF-mutant colorectal cancer

Dr. Kopetz, Professor, GI Medical Oncology, MD Anderson Cancer Center, tells us about the updated data from the phase III ...

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Stefan Kasper, MD, explains the dosing and administration schedule of cetuximab

Dr. Kasper, Professor of Oncology, University Hospital West German Cancer Center, Essen, explains the dosing and administration schedule of cetuximab ...

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Marwan Fakih, MD, considers implications from the AMG 510 trial

Dr. Fakih, Professor, Department of Medical Oncology & Therapeutics Research, Section Head, GI Medical Oncology, City of Hope, considers the ...

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Marwan Fakih, MD, on whether MSI-high is a “must-have” biomarker for CRC patients

Dr. Fakih, Professor, Department of Medical Oncology & Therapeutics Research, Section Head, GI Medical Oncology, City of Hope, on MSI-high ...

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Marwan Fakih, MD, discusses the Phase 1 trial evaluating AMG 510 in CRC and NSCLC

Dr. Fakih, Professor, Department of Medical Oncology & Therapeutics Research, Section Head, GI Medical Oncology, City of Hope, discusses the ...

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Marwan G. Fakih, MD, on combining regorafenib + checkpoint inhibition in advanced CRC

Dr. Fakih, Medical Director, Judy & Bernard Briskin Center for Clinical Research, Co-Director, Gastrointestinal Cancer Program, Section Head, GI Medical ...

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Marwan G. Fakih, MD, on why AMG 510 seems promising in colorectal and lung cancers

Dr. Fakih, Medical Director, Judy & Bernard Briskin Center for Clinical Research, Co-Director, Gastrointestinal Cancer Program, Section Head, GI Medical ...

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Stefan Kasper, MD, provides updates on the BEACON trial in BRAF-mutant CRC

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Scott Kopetz, MD, shares updates from the BEACON trial in BRAF-mutant colorectal cancer

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Stefan Kasper, MD, explains the dosing and administration schedule of cetuximab

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Marwan Fakih, MD, considers implications from the AMG 510 trial

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Marwan Fakih, MD, on whether MSI-high is a “must-have” biomarker for CRC patients

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Marwan Fakih, MD, discusses the Phase 1 trial evaluating AMG 510 in CRC and NSCLC

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Marwan G. Fakih, MD, on combining regorafenib + checkpoint inhibition in advanced CRC

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Marwan G. Fakih, MD, on why AMG 510 seems promising in colorectal and lung cancers

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Marwan G. Fakih, MD, describes the role of KRAS inhibitors in colorectal cancer

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Leonard Saltz, MD, offers opinion on the value of of liquid biopsy in colorectal cancer treatment

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Leonard Saltz, MD, offers opinion on molecular profiling in the treatment of CRC

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Leonard Saltz, MD, considers the complexities of managing metastatic colorectal cancer

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Leonard Saltz, MD, on whether data presented at ASCO '19 will change the way we treat CRC

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John Strickler, MD, on how next-generation sequencing fits into treatment of mCRC

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Raymond Wadlow, MD, regarding BSC vs. combination checkpoint inhibitors in advanced CRC

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Richard Kim, MD, regarding the use of regorafenib in treatment of colorectal cancer

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Axel Grothey, MD, on the CCTG CO.26 trial in advanced refractory CRC presented at GI 2019

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Axel Grothey, MD, on the use of regorafenib in the management of advanced CRC

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Axel Grothey, MD, on patient selection & treatment algorithms in 2nd and 3rd line CRC

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Alan Venook, MD, tells us whether ctDNA is a valid treatment response in CRC

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Axel Grothey, MD, considers the role of circulating tumor DNA (ctDNA)

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Alan Venook, MD, discusses next generation sequencing and mCRC treatment

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Axel Grothey, MD, elaborates on next generation sequencing and mCRC

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Philip Philip MD, PhD, FRCP, on neoadjuvant chemotherapy & upfront surgery in pancreatic cancer

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Jeffrey A. Meyerhardt, MD, on genetic testing in newly diagnosed mCRC

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Jeffrey A. Meyerhardt, MD, shares thoughts on checkpoint inhibitors in adjuvant CRC

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Howard Hochster, MD, considers next generation sequencing and mCRC treatment decisions

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Jeffrey A. Meyerhardt, MD, on managing 2nd and 3rd line mCRC patients

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Howard Hochster, MD, on the management of mCRC patients receiving regorafenib

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Jeffrey A. Meyerhardt, MD, on whether regorafenib is becoming more tolerable for mCRC patients

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Howard Hochster, MD, explains how to manage 2nd and 3rd line mCRC patients

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Jeffrey A. Meyerhardt, MD, considers the BEACON study in BRAF mutated metastatic colorectal cancer

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Howard Hochster, MD, regarding the role of genetic testing in mCRC

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Atrayee Basu Mallick, MD, shares highlights from the 2018 ASCO Annual Meeting

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Atrayee Basu Mallick, MD, considers how tumor-sidedness impacts CRC treatment algorithms

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Atrayee Basu Mallick, MD, discusses how nivolumab is incorporated into mCRC treatment algorithms

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Atrayee Basu Mallick, MD, tells us about the outcomes of the Checkmate 142 study in mCRC

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Atrayee Basu Mallick, MD, on the addition of vemurafenib to the NCCN guidelines for mCRC

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Atrayee Basu Mallick, MD, regarding the impact of stage & mismatch repair status on CRC treatment

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Atrayee Basu Mallick, MD, offers opinion on immunotherapy in colorectal cancer

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John Leighton, MD, on the headline “Immunotherapy Now Standard for Some Patients With CRC”

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John Leighton, MD, explains how tumor sidedness impacts CRC treatment algorithms

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John Leighton, MD, comments on the outcomes of Checkmate 142 in mCRC

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Howard Hochster, MD, regarding the outcomes of the PRODIGY7 study in mCRC

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Howard Hochster, MD, comments on the VALENTINO study presented at ASCO 2018

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Richard Goldberg, MD, elaborates on the outcomes of the PRODIGY7 study in mCRC patients

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Al Benson III, MD, FACP, on how tumor-sidedness impacts colorectal cancer treatment algorithms

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Al Benson III, MD, FACP, discusses the role of I-O and immunotherapy combinations when treating CRC

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Al Benson, MD, on what molecular markers are most important to test for when treating CRC patients

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Steven J. Cohen, MD, outlines the results of the Checkmate 142 study in mCRC patients

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Steven J. Cohen, MD, discusses vemurafenib and the NCCN guidelines for mCRC patients

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Steven J. Cohen, MD, provides insight into sequencing and efficacy outcomes in 2nd line mCRC

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Steven J. Cohen, MD, describes how tumor sidedness impacts treatment decisions in mCRC

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Steven J. Cohen, MD, regarding combination atezolizumab + cobimetinib in mCRC patients

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Steven J. Cohen, MD, considers the improvement in duration of therapy examined in the ReDOS study

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Steven J. Cohen, MD, on how to dose patients receiving regorafenib as a result of the ReDOS study

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Philip Philip, MD, PhD, FRCP, discusses the impact of the Checkmate 142 study on mCRC

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Richard Kim, MD, offers opinion on the ReDOS study and dose escalation of regorafenib

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Scott Kopetz, MD, PhD, FACP, on the potential of binimetinib + immunotherapy in mCRC patients

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Scott Kopetz, MD, PhD, FACP, regarding molecular profile matching in trials with mCRC patients

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Scott Kopetz, MD, PhD, FACP, on the implications of the BEACON Phase 3 study in BRAF-mutant mCRC

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Jeffrey Meyerhardt, MD, MPH, considers the addition of vemurafenib to the NCCN guidelines for mCRC

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Scott Kopetz, MD, PhD, FACP, explains how nivolumab is being incorporated into mCRC treatment

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Scott Kopetz, MD, PhD, FACP, tells us about the outcomes of Checkmate 142 in mCRC patients

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Scott Kopetz, MD, PhD, FACP, considers the addition of vemurafenib to the NCCN guidelines for mCRC

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Scott Kopetz, MD, PhD, FACP, discusses the incidence of BRAF mutation in CRC patients

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Howard Hochster, MD, outlines the results of the Checkmate 142 study in mCRC patients

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Howard Hochster, MD, considers patient age and the OncotypeDX recurrence score in CRC

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Alan Venook, MD, considers how immunotherapy is being integrated into CRC treatment algorithms

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Alan Venook, MD, on the impact of dose escalation of regorafenib in mCRC patients

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Howard Hochster, MD, offers opinion on the ReDOS study and dose escalation of regorafenib

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Jeffrey Meyerhardt, MD, discusses BRAF+ mutation metastatic CRC and vemurafenib

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Jeffrey Meyerhardt, MD, regarding the optimal duration of therapy in stage III colon cancer patients

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Howard Hochster, MD, discusses the optimal duration of FOLFOX therapy in stage III colon cancer

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Howard Hochster, MD, on the impact of SWOG 1406 in treating BRAF mutation positive CRC patients

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Richard Goldberg, MD, FASCO, regarding the optimal duration of therapy in stage III colon cancer

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Richard Goldberg, MD, FASCO, defines “high-risk” and “low-risk” stage III colon cancer patients

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Philip Philip, MD, on what we’ve learned about the duration of therapy in the adjuvant CRC setting

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John L. Marshall, MD, discusses which molecular tests to order when determining treatment approach

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Jeffrey A. Meyerhardt, MD, talks about the DFCI wellness study

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Philip Philip, MD, on which molecular tests to order for a newly diagnosed CRC patient

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Philip Philip, MD, on integrating immunotherapy into existing treatment regimens for CRC patients

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Alan P. Venook, MD, explains how the 80405 study and its impact on treatment guidelines

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Alan P. Venook, MD, on integrating immunotherapy into existing treatment regimens for CRC patients

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Howard S. Hochster, MD, explains the outcomes of the phase 2 study in BRAF mutated CRC patients

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Howard S. Hochster, MD, discusses if genetic profiling has changed treating CRC patients

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Howard S. Hochster, MD, provides perspective on how to use TAS-102 and regorafenib in CRC patients

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Tanios Bekaii-Saab, MD, on developing effective immunotherapies in CRC patients

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Tanios Bekaii-Saab, MD, on progress in developing immunotherapies in non MSI- High CRC patients

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Bert O’Neill, MD, on making immunotherapy more effective in mCRC

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Alan Venook, MD on whether CALGB/SWOG 80405 study provides guidance on therapeutic regimen

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Tanios Bekaii-Saab, MD, on how clinicians factor economics into therapeutic decision making

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Howard Hochster, MD on the reliability of MSI-High as a predictor of response to nivolumab

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Howard Hochster, MD on the economic benefit seen in CALGB/SWOG 80405

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Howard Hochster, MD talks progress in the development of effective non MSI-High immunotherapies

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Tanios Bekaii-Saab, MD, on performance status when selecting mCRC, 3rd line treatment therapy

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Tanios Bekaii-Saab, MD, comments on dosing regorafenib (Stivarga) in 3rd line treatment of mCRC

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Tanios Bekali-Saab, MD, on utilizing regorafenib (Stivarga) and trifluridine (Lonserf)

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Tanios Bekaii-Saab, MD on MSI-High as an mCRC response predictor to nivolumab (Opdivo)

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Tanios Bekali-Saab, MD, tells us whether KRAS is a definitive biomarker in mCRC patients

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Tanios Bekaii-Saab, MD on outcomes of CALGB/SWOG 80404 and potential impact

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Tanios Bekaii-Saab, MD, comments on outcomes of CALGB/SWOG 80404 regarding primary site of tumor

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Jeffrey A. Meyerhardt, MD explains results from the phase 3 CALGB/SWOG 80405 study

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Jeffrey A. Meyerhardt, MD discusses the phase 3 CALGB/SWOG 80405 study

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Jeffrey A. Meyerhardt, MD explains how OS from primary site of tumor may impact treatment

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Jeffrey A. Meyerhardt, MD on the reliability of MSI-High as a predictor of response in mCRC

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Jeffrey A. Meyerhardt, MD, discusses immunotherapy in MSI-Stable CRC patients

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Jeffrey A. Meyerhardt, MD explains integration of Stivarga and Lonserf in later lines of treatment

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Jeffrey A. Meyerhardt, MD weighs in on the economic vs efficacy outcomes in CALGB/SWOG 80405

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Jeffrey A. Meyerhardt, MD, explains matching mutations and markers to therapies in CRC patients

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Philip Philip, MD on Stivarga (regorafenib) dosage in 2nd line treatment of mCRC

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Philip Philip, MD explains how to integrate regorafenib and trifluridine for 2nd line mCRC treatment

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Philip Philip, MD on the importance of ipilimumab prior to nivolumab in mCRC patients

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Philip Philip, MD on the reliability of MSI-High as a predictor of response to Opdivo in mCRC

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Philip Philip, MD discusses phase 3 CALGB/SWOG 80405 study outcomes

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Philip Philip, MD on what is impressing him at ASCO 2016 in CRC

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Jeffrey A. Meyerhardt, MD on PD-1 or PD-L1 treatment strategies for MSI-Stable mCRC patients

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Bert O'Neil, MD discusses decision making based on toxicities factor for later lines of mCRC therapy

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Howard Hochster, MD explains outcomes from the phase 3 CALGB/SWOG 80405 study

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Howard Hochster, MD on mCRC treatment changes due to primary site of tumor impact.

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Howard Hochster, MD on performance status importance in selecting treatment algorithms

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Richard Goldberg, MD, talks patient response with the combination of MEK and PD-1 inhibitors

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Richard M. Goldberg, MD, FASCO on KRAS wild type or mutant in right or left-sided mCRC patients

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Richard M. Goldberg, MD, FASCO on regimen preference in mCRC 1st line treatment

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Bert O'Neil, MD on integrating regorafenib and trifluridine into later lines of mCRC treatment

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Bert O'Neil, MD on the importance of choosing mCRC treatment based on primary tumor site

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Alan Venook, MD discusses development of immunotherapies for non MSI-High CRC patients

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Alan Venook, MD, balancing economics with the efficacy outcomes seen in 80405

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Alan Venook, MD relays the optimal dose for regorafenib (Stivarga) in the 2nd line treatment of mCRC

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Alan Venook, MD on integrating regorafenib and trifluridine into the 2nd line treatment of mCRC

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Alan Venook, MD on reliability of MSI-High predictor fpr response to nivolumab (Opdivo) in mCRC

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Alan Venook, MD relates data presented in EPIC study relates to CALGB/SWOG 80405

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Choosing which EGFR inhibitor to use in second line treatment of mCRC patients At ASCO GI 2016

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RECOURSE versus CORRECT and CONCUR trials evaluating regorafenib in metastatic CRC at ASCO GI 2016

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Integrating TAS-102 and regorafenib into your therapeutic algorithm for advanced CRC at ASCO GI 2016

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RECOURSE trial compared to CORRECT and CONCUR evaluating regorafenib in mCRC

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Biggest questions facing the treatment of colorectal cancer ASCO GI 2016

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How has the last 10 years changed the way you treat metastatic colorectal cancer ASCO GI 2016

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Immunotherapy, MET, and HER 2+ research is the future of colorectal cancer treatment ASCO GI 2016

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Regorafenib experience and integrating TAS-102 for advanced CRC ASCO GI 2016

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ERCC1 not a valid prognostic or predictive factor in advanced CRC ASCO GI 2016

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STEAM trial may not change treatment paradigm for metastatic CRC ASCO 2016

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RAS mutation in patients with metastatic colorectal cancer ASCO GI 2016

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ASCO GI 2016 Optimal Dosage Using Regorafenib Colorectal Cancer

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Immunotherapy Shows Promise in MSI-High Colorectal Cancer

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Future of TAS-102 and regorafenib for patients with colorectal cancer

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Shirish M. Gadgeel MBBS, comments on significant studies in ALK+ NSCLC from ESMO 2019

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Véronique Diéras, MD, on the optimal setting in which to receive a PARP inhibitor

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Robert L. Coleman, MD, FACOG, FACS, on takeaways from the ovarian plenary session at ESMO '19

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Christian Rolfo, MD, PhD, MBA, on the development of RET-Fusion in NSCLC

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Véronique Diéras, MD, elaborates on the BROCADE 3 study presented at ESMO 2019

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Robert L. Coleman, MD, FACOG, FACS, on how veliparib factors into ovarian cancer treatment

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Brian Van Tine, MD, considers the role of real-world outcomes in the treatment of sarcoma

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Jason J. Luke, MD, FACP, on the role of CAR-Ts in the treatment of solid tumors

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Ahmed Kaseb, MD, elaborates on the phase 1b study investigating atezolizumab + bevacizumab in HCC

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Christopher J. Hoimes, MD, comments on the design and outcomes of KEYNOTE-866

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Christopher J. Hoimes, MD, regarding the EV-103 study presented at ESMO 2019

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Joyce O’Shaughnessy, MD, shares relevant findings from the MONARCH-2 trial

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Geoffrey Oxnard, MD, on the effectiveness of lorlatinib as a frontline agent in ALK+ NSCLC

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Joyce O’Shaughnessy, MD, shares results of the Impassion130 trial presented at ESMO 2019

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Michael J. Birrer, MD, PhD, considers the benefits of various PARP inhibitors in ovarian cancer

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David Spigel, MD, tells us about the results of CheckMate-227 presented at ESMO 2019

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Suresh Ramalingam, MD, on how the FLAURA trial may impact care for EGFR-mutated NSCLC

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Michael J. Birrer, MD, PhD, regarding BRCA status in newly diagnosed ovarian cancer

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Michael J. Birrer, MD, PhD, on the role of maintenance therapy in newly diagnosed ovarian cancer

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Michael J. Birrer, MD, PhD, elaborates on the outcomes from the FORWARD I study

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Michael Birrer, MD, on the key takeaways from the ovarian plenary session in ovarian cancer at ESMO 2019

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David Spigel, MD, on the use of genomic markers like TMB to guide 1st NSCLC treatment

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Joyce O’Shaughnessy, MD, on differentiating CDK4/6 inhibitors

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Geoffrey Oxnard, MD, on the FLAURA study impacting treatment selection in EGFR mutant lung cancer

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Suresh Ramalingam, MD, discusses the results of CheckMate 227 in advanced NSCLC patients

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Nader Sanai, MD, on the role of ribociclib in the management of gliomas

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Suresh Ramalingam, MD, FASCO, shares results from the FLAURA trial presented at ESMO 2019