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Second Drug Targeting KRAS G12C Shows Benefit in Mutated Non-Small-Cell Lung Cancer

(ELCC 2021 Virtual) Mar 25, 2021 - Clinical activity with a second drug inhibiting KRASG12C confirms its role as a therapeutic target in patients with advanced non-small-cell lung cancer (NSCLC) harbouring this mutation, according to results from a study with the KRASG12C inhibitor adagrasib reported at the European Lung Cancer Virtual Congress 2021. “As we strive to identify the oncogenic driver in more and more of our patients with NSCLC, it becomes critical that we develop therapies that can target these identified oncogenic drivers,” said lead author Gregory Riely, from Memorial Sloan Kettering Cancer Center, New York, USA.

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H. Jack West, MD (Posted: March 25, 2021)

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Important work, especially data on co-mutations with KRAS G12C. There's a great deal more to learn in coming years. For now, these data with adagrasib look slightly superior to what we've seen with sotorasib, but we await far more data on combinations and in different settings in NSCLC in the coming years. I'm very hopeful that KRAS G12C is poised to become a large molecular subset for whom we'll have a greater understanding and steadily improving treatment options in the coming years.

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