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MSD Withdraws Keytruda’s US Indication For Small Cell Lung Cancer


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Featured Oncology News Headlines

MSD Withdraws Keytruda’s US Indication For Small Cell Lung Cancer

(PMLiVE [UK]) Mar 2, 2021 - MSD (Merck & Co) has voluntarily withdrawn the US indication for its checkpoint inhibitor Keytruda in metastatic small cell lung cancer (SCLC).

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A Covid Vaccine Side Effect, Enlarged Lymph Nodes, Can Be Mistaken for Cancer

(New York Times) Mar 2, 2021 - Coronavirus vaccinations can cause enlarged lymph nodes in the armpit or near the collarbone, which may be mistaken for a sign of cancer.

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Study Finds Missing Annual Mammogram Increases Risk of Death from Breast Cancer

(American Cancer Society) Mar 2, 2021 - Attendance at regular mammography screening substantially reduces the risk of dying from breast cancer, according to a large study of over half a million women, funded by the American Cancer Society and published in the journal Radiology.

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Featured Editorial Board Comments

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Cancer Patients Often Can’t Get Full Care With Covid-19 Bogging Down Medical Facilities
Ted Okon (Posted: March 02, 2021) - "This article is biased from the perspective of hospital-based cancer care. Independent community oncology practices have stayed open to treat the nation's cancer patients during the pandemic, even tak..."

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Oncology Clinical News Headlines

 

Significant New Findings about Breast and Ovarian Cancer in Patients from the Caribbean

(University of Miami) Mar 1, 2021 - In this study, among Caribbean-born individuals with breast and ovarian cancer, 1 in 7 had hereditary breast and ovarian cancer. The proportion of hereditary breast and ovarian cancer varied by island and each island had a distinctive set of variants.

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Encouraging Early Results Seen with Novel MEDI1191 in Advanced Tumours

(ESMO TAT 2021) Mar 1, 2021 - Preliminary data with IL-12 mRNA administered by intratumoural injection in combination with intravenous durvalumab.

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Why Some Melanoma Patients Do Not Respond to Immunotherapy

(CUIMC) Mar 1, 2021 - By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients—across cancer types—do not respond, and in most cases, scientists are at a loss as to why.

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New Immunotherapy Drugs Target Two Evasive Cancer-Driving Proteins

(Science Magazine) Mar 1, 2021 - Bispecific antibodies show promise in mice against hard-to-treat tumors.

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HKBU Develops Dual-Targeting Drug For EBV-Related Cancers

(HKBU) Mar 2, 2021 - A Hong Kong Baptist University-led (HKBU) research team has developed a novel drug which has the potential to become a next-generation treatment for cancers associated with Epstein-Barr virus (EBV).

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Study Identifies Two Genes Contributing To Hispanic, Latino Children With Leukemia Faring Worse Than Other Groups

(Loma Linda University) Mar 1, 2021 - Loma Linda University Health researchers have pinpointed two genetic markers that could be responsible for worse health outcomes in Hispanic and Latino children with leukemia — their findings published last month in the journal Leukemia.

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INOVIO Announces Positive Results from REVEAL 1, a Phase 3 Pivotal Trial Evaluating VGX-3100, its DNA-based HPV Immunotherapy for the Treatment of High-grade Precancerous Cervical Dysplasia Caused by HPV-16 and/or HPV-18

(MarketWatch) Mar 1, 2021 - INOVIO today announced it met primary and secondary endpoints among all evaluable subjects for the REVEAL 1 trial.

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Aileron Therapeutics Announces Enrollment Expansion for Upcoming Phase 1b Clinical Trial of ALRN-6924 in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)

(Yahoo! Finance) Mar 2, 2021 - Placebo-controlled trial anticipated to enroll 60 patients with advanced p53-mutated NSCLC undergoing treatment with first-line carboplatin plus pemetrexed. Regulatory pathway now clarified for chemoprotection with recent U.S. FDA approval of first-generation chemoprotective drug for patients with extensive-stage small cell lung cancer.

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NGM Bio Initiates Expansion of Ongoing Phase 1b Proof-of-Concept Study of NGM120 in Patients with Metastatic Pancreatic Cancer

(NGM Bio) Mar 2, 2021 - NGM Biopharmaceuticals, Inc. today announced it has dosed the first patient in an expansion of its ongoing Phase 1b proof-of-concept study of NGM120 in patients with metastatic pancreatic cancer.

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Featured Podcasts

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Prostate Cancer – Robert Figlin, MD, and Neeraj Agarwal, MD, discuss clinical progress in prostate cancer

Robert Figlin, MD, Steven Spielberg Family Chair in Hematology-Oncology, Cedars-Sinai Medical Center and Neeraj Agarwal, MD, Professor of Medicine, Huntsman Cancer Institute, Presidential Endowed Chair of Cancer Research , Co-Leader, HCI Experimental Therapeutics Program, Director, Center of Investigational Therapeutics, Director, Genitourinary Oncology Program, Huntsman Cancer Institute, University of Utah, discuss clinical progress in prostate cancer

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Featured Videos

Eleni Efstathiou, MD, PhD, regarding the PROSPER clinical trial from ASCO GU 2021

Dr. Efstathiou, Associate Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, tells us about the PROSPER clinical trial investigating the role of enzalutamide in non-metastatic castration-resistant prostate cancer (nmCRPC) as presented at ASCO GU 2021 and considers whether PSA is an accurate marker for survival
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Oncology Business & Policy News Headlines

Day 1 at AMCCBS: COVID Fallout and Policy Concerns

(ACCCBuzz Blog) Mar 2, 2021 - The ACCC 47th Annual Meeting & Cancer Center Business Summit (AMCCBS) opened today with an overview of the rapidly changing national political climate and what it may mean for healthcare policy in the months and years ahead.

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NCI Statement On Ending Structural Racism In Biomedical Research

(NCI) Mar 2, 2021 - As one of the 27 institutes and centers that make up NIH, the National Cancer Institute stands with Dr. Francis Collins and the entire NIH in supporting UNITE.

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G1 Therapeutics and Boehringer Ingelheim Announce Commercial Availability of COSELA™ (trilaciclib), the Only FDA-Approved Multilineage Myeloprotection Therapy to Decrease the Incidence of Chemotherapy-Induced Myelosuppression

(G1 Therapeutics) Mar 2, 2021 - G1 Therapeutics, Inc. and Boehringer Ingelheim today announced that COSELA™ (trilaciclib) for injection is now available in the U.S.

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Strata Oncology, Pfizer Partner to Explore New Biomarker Indications for FDA-Approved Drugs

(GenomeWeb News) Mar 2, 2021 - Strata Oncology on Tuesday said it will conduct a study to evaluate new biomarker-defined indications for targeted therapies and immunotherapies already approved by the US Food and Drug Administration.

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Myriad Genetics, Intermountain Healthcare Collaborate for Cancer Testing Service

(GenomeWeb News) Mar 2, 2021 - Myriad Genetics on Tuesday said it will combine its hereditary cancer risk tests and companion diagnostics in a single offering with tumor tissue profiling services offered through Intermountain Healthcare's Intermountain Precision Genomics service.

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Opinion: Medicare Loophole For Screening Colonoscopies Is Fixed — What Does This Mean For Patients?

(The Hill) Mar 1, 2021 - After nearly a decade of tireless advocacy, the Removing Barriers to Colorectal Cancer Screening Act, nicknamed the “Medicare Loophole” bill, finally made it across the finish line.

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NYU Oral Cancer Center Awarded NIH Grant to Study Interplay Between Oral Cancer and Nerves

(NYU) Mar 1, 2021 - Research to investigate sensitization and activation of “capsaicin receptor” on pain-sensing nerves by cancer mediators, and how these nerves promote cancer progression.

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Greater Washington Oncology Associates Joins the American Oncology Network, LCC

(AON) Mar 1, 2021 – American Oncology Network, LLC (AON), a high-growth national network of independent community oncologists, is pleased to announce that Greater Washington Oncology Associates in Silver Spring, Md. joined AON effective March 1, 2021.

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OBR Resources

News Story Commentary

Cancer Patients Often Can’t Get Full Care With...

This article is biased from the perspective of hospital-based cancer care. Independent community on...

Ted Okon

2021-03-02


FDA Approves Cemiplimab-rwlc For Non-Small Cell Lung...

This approval now gives us a third option for the same clinical setting in which we already have pe...

H. Jack West, MD

2021-02-23


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Broader Healthcare & Pharma News Headlines

 

Biden To Announce ‘Historic Partnership’: Merck Will Help Make Johnson & Johnson Coronavirus Vaccine, Officials Say

(Washington Post) Mar 2, 2021 - President Biden will announce Tuesday that pharmaceutical giant Merck will help make Johnson & Johnson’s single-shot coronavirus vaccine — an unusual pact between fierce competitors that could sharply boost the supply of the newly authorized vaccine, according to senior administration officials.

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The Trump Administration Quietly Spent Billions In Hospital Funds On Operation Warp Speed

(STAT) Mar 2, 2021 - The Trump administration quietly took around $10 billion from a fund meant to help hospitals and health care providers affected by Covid-19 and used the money to bankroll Operation Warp Speed contracts, four former Trump administration officials told STAT.

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CVS, Walgreens Look for Big Data Reward From Covid-19 Vaccinations

(Wall Street Journal) Mar 2, 2021 - Administering Covid-19 vaccines comes with a valuable perk for retail pharmacies: access to troves of consumer data.

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Last-Minute FDA Advisory Panel Puts a Kink in Approval Hopes for Anemia Drug

(BioSpace) Mar 2, 2021 - The U.S. FDA has decided to put together an advisory committee meeting of outside experts to review a New Drug Application for roxadustat, FibroGen and its partner AstraZeneca’s investigational anemia therapy.

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NIH Stands Against Structural Racism In Biomedical Research

(NIH) Mar 1, 2021 - Although addressing the COVID-19 pandemic has been front and center for NIH over the past year, we have not forgotten another significant challenge confronting the health of our nation — systemic and structural racism.

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